相关实验视频
Updated: Jun 3, 2025

05:19
Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
10.1K
探索食管胃结形态和收缩整体:对耐火性胃食管逆流病的影响病理生理学
Sihui Lin1, Zhilong Chen1, Wei Jiang1,2
1Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Xiamen Branch, Xiamen, China.
Scandinavian journal of gastroenterology
|January 7, 2025
概括
食管胃结 (EGJ) 形态和收缩整体 (EGJ-CI) 是耐火性胃食管逆流病 (RGERD) 的关键指标. 较低的EGJ-CI和特定的形态预测了病态反流,有助于治疗决策.
科学领域:
- 胃肠病学 胃肠病学
- 食道生理学 食道生理学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 耐药性胃食道逆流性疾病 (RGERD) 带来了重大的临床挑战.
- 了解食管胃结 (EGJ) 形态和功能的作用对于管理RGERD至关重要.
研究的目的:
- 评估EGJ形态和EGJ收缩整体 (EGJ-CI) 在RGERD患者的临床意义.
- 确定病理性反流的预测因素,并指导治疗策略.
主要方法:
- 144名RGERD患者的队列接受了评估,包括症状评分,通过内镜进行GERD分类,24小时pH阻抗监测和高分辨率食道计量 (HREM).
- HREM被用来测量EGJ形态和EGJ-CI,以及其他食道运动参数.
主要成果:
- 在80.6%,13.9%和5.6%的受试者中分别发现了EGJ形态 (I,II,III类型).
- 下食道 (LES) 和膜 (CD) 之间的分离增加与EGJ-CI降低相关 (p < 0.005).
- 与I型相比,EGJ类型II和III与较高的酸暴露时间,DeMeester得分和阻抗反流时间有关 (p <0.05).
- 24.8 mmHg·cm的EGJ-CI切线区分了病态反流,具有68%的灵敏度和72.3%的特异性 (AUC = 0.693).
- 较低的EGJ-CI (<24.8 mmHg·cm) 和无效的食道运动 (IEM) 是RGERD的独立风险因素 (分别为OR=2.5和2.4).
结论:
- 在RGERD患者中,EGJ-CI是评估EGJ屏障功能的关键参数.
- 脑形态和EGJ-CI有助于预测病态反流并选择合适的外科候选人.
- 这些发现强调了HREM在RGERD综合评估中的重要性.
相关概念视频
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology
282
Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
282
Gastroesophageal Reflux Disease II: Clinical Features and Management
54
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
54
Esophagus
548
The esophagus, a muscular conduit linking the pharynx and stomach, measures roughly 10 inches (25.4 cm) and sits behind the trachea. It remains collapsed when not swallowing. The esophagus follows a predominantly straight path through the thoracic mediastinum and enters the abdominal cavity through a diaphragmatic opening known as the esophageal hiatus.
The movement of edibles from the pharynx into the esophagus is facilitated by the upper esophageal sphincter, which is formed primarily by the...
The movement of edibles from the pharynx into the esophagus is facilitated by the upper esophageal sphincter, which is formed primarily by the...
548
Esophageal Strictures-I: Introduction
64
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
64
Gastric Motility
384
Gastric motility is the coordinated contraction and relaxation of stomach muscles that convert ingested food into chyme, a semi-liquid substance ready for further digestion in the intestines. The process begins with the vagus nerve inducing the relaxation of the smooth muscles in the fundus and body of the stomach, allowing these regions to expand and accommodate up to approximately 1.5 liters of food and liquid.
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
384
Gross Anatomy of the Stomach
461
The human stomach is a vital part of the digestive system, performing multiple functions. It is located within the peritoneum, a serous membrane that lines the abdominal cavity. The stomach plays a central role in processing food substances and interacts with other digestive organs through coordinated digestive processes. The stomach has a characteristic J-shape and is divided into four main regions. The cardia is the first section where the esophagus connects to the stomach and is the entry...
461

