прополис补充剂对毒性的影响,与大鼠和肝功能障碍相关
Huseyin Ayhan1, Caglar Adiguzel2, Keziban Korkmaz Bayram3
1Vocational School of Health Services, Ankara Yıldırım Beyazıt University, Çubuk, Ankara 06760, Turkey.
概括
прополис在老鼠中显示出对化毒性的保护作用. 它改善了生物化学,血液学和炎症标志物,以及基因和蛋白质表达,在暴露的动物中.
科学领域:
- 毒理学 毒理学 毒理学
- 自然产品 化学 化学
- 生物化学 生物化学
背景情况:
- (Cd) 是一种有毒的重金属,具有广泛的工业应用,并对公共健康产生重大影响.
- 蜂是蜜蜂收集的天然树脂混合物,具有已知的抗氧化和抗炎性质.
研究的目的:
- 评估的保护潜力,防止化诱导的毒性在老鼠.
- 评估在暴露于后对血液,肝脏和组织的影响.
主要方法:
- 在28天的时间里,老鼠通过输卵管接受了 прополис,化或两者的组合.
- 评估了血清生物化学参数 (ALT,AST,BUN,LDH,尿素,尿酸,肌),血液学参数 (红细胞,血红蛋白,血红素) 和细胞因子水平 (IL-1β,IL-6).
- 评估了Casp-3,p53,Tnf-α的mRNA表达和HSP70,HSP90,GRP78的蛋白质水平,以及组织病理学和免疫组织化学分析.
主要成果:
- 与对照组相比,化暴露显著改变了生物化学,血液学和细胞因子配置.
- 在治疗的老鼠中观察到基因表达 (Casp-3,p53,Tnf-α) 和蛋白质水平 (HSP70,HSP90,GRP78) 的显著变化.
- прополис与化的同时使用导致生物化学,血液学和炎症标志物的改善,以及基因和蛋白质表达和组织组织学的正常化.
结论:
- прополис对化的毒性具有显著的保护作用.
- 研究结果表明,可以在生物化学,细胞和分子层面减轻引起的损伤.
- 是一种潜在的天然治疗剂,可以抵消重金属的毒性.
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