术前补充β-基β-甲基酸盐,氨酸和谷氨酸对心脏手术的影响:一项随机对照试验
Masato Ogawa1, Seimi Satomi-Kobayashi2, Naofumi Yoshida3
1Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine, Hyogo, Japan; Department of Rehabilitation Science, Osaka Health Science University, Osaka, Japan; Department of Public Health, Kobe University Graduate School of Health Sciences, Hyogo, Japan.
Clinical nutrition (Edinburgh, Scotland)
|January 7, 2025
概括
手术前补充β-基β-甲基酸盐 (HMB) 改善了心脏手术后老年人的运动能力和身体功能. 这种干预措施还减少了住院时间,但没有产生不良影响.
科学领域:
- 老年医学 老年医学
- 心血管外科心血管外科
- 营养科学 营养科学
背景情况:
- 身体功能对于心脏手术后老年人的结果至关重要.
- 贝塔-基-贝塔-甲基酸盐 (HMB) 通过促进代谢和抑制代谢,支持肌肉健康.
- 在此之前,HMB对老年心脏手术患者的影响是未知的.
研究的目的:
- 评估手术前HMB补充剂对术后身体功能的影响.
- 评估HMB对接受心脏手术的老年人并发症的影响.
主要方法:
- 进行了一项单中心,开放标签,随机对照试验.
- 65岁以上的患者在手术前至少两周接受HMB (1200毫克) 加上l-胺 (7000毫克) 和l-阿尔金因 (7000毫克) 或没有干预.
- 主要结局是6分钟的步行距离 (6MWD);次要结局包括并发症,肌肉功能和住院.
主要成果:
- 与对照组相比,HMB组在手术前和手术后的6MWD显著改善 (P<0.05).
- 肌肉力量和身体表现在HMB组显著增强.
- HMB组的住院时间较短 (16.1天 vs 20.4天,P=0.03),没有报告的不良事件. 肌肉质量没有显著差异.
结论:
- 在手术前补充HMB可以提高老年心脏手术患者的术后运动能力和身体功能.
- 补充HMB导致住院时间缩短.
- 干预是安全的,并没有对肌肉产生负面影响.
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