相关实验视频

Updated: Jun 3, 2025

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Published on: May 1, 2015

[高风险燃烧性多发性骨髓瘤风险分层和治疗方面的进展]

J Q Zhou¹, M Hao¹, G An¹

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China Tianjin Institutes of Health Science, Tianjin 301600, China.

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

|January 7, 2025

概括

识别高风险燃烧多发性骨髓瘤 (SMM) 是至关重要的. 本综述涵盖了SMM患者风险分层和治疗策略的进展,这些患者可能会发展为多发性髓瘤 (MM).

科学领域:

血液学血液学血液学
在瘤学瘤学.
临床研究临床研究

背景情况:

燃烧多发性髓瘤 (SMM) 患者的预后是可变的.
一部分SMM患者在两年内面临向多发性骨髓瘤 (MM) 进展的高风险.
目前的风险模型缺乏对高风险的SMM的一致定义.

研究的目的:

审查高风险中小企业风险分层的当前进展情况.
检查高风险SMM的不断发展的治疗策略.
突出了对最佳治疗计划的进一步研究的需要.

主要方法:

审查现有的风险模型及其预测性能.
分析生物标志物和新技术在风险评估中的应用.
对高风险SMM的现有和新兴治疗方法的评估.

主要成果:

结合生物标志物和技术可以提高风险模型的预测准确性.
针对高风险的SMM正在探索新型药物,其中一些药物显示改善了无进展生存率.
强化多药疗法显示有望实现深度缓解,但需要通过比较研究进一步验证.

结论:

精确的风险分层对于管理SMM至关重要.
虽然新的治疗方法有好处,但需要进一步的研究来确定高风险SMM患者的最佳治疗策略和生存益处.
对这种患者群体来说,对治疗计划的持续探索至关重要.

更多相关视频

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

Published on: July 15, 2015

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

相关概念视频

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...