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在固定假肢患者中对supragingival斑块进行微生物社区分析

Lingjun Cui¹, Xin Bao², Yueyang Yan³

¹Graduate student, Department of Stomatology, The Fifth Affiliated Hospital of Sun Yat-sen University, Xiangzhou, Zhuhai City, Guangdong, PR China.

The Journal of prosthetic dentistry

|January 7, 2025

概括

固定假肢改变了牙上方斑块微生物组合,增加了牙周病原体. 陶冠比金属陶的微生物影响较小,突出显示了牙周健康的材料选择.

科学领域:

牙周病学牙周病学
微生物学微生物学
生物材料是一种生物材料.

背景情况:

保持牙周组织和与固定假肢是长寿至关重要的.
固定假牙可能会增加支柱牙的牙周病变的风险.
有限的研究存在于假牙和天然牙之间的supragingival斑块生物膜差异.

研究的目的:

为了研究固定假肢上的supragingival斑块生物膜微生物组成.
将假牙上的斑块微生物与天然牙上的斑块微生物进行比较.
为了利用16S核糖体脱氧核糖核酸 (rDNA) 测序进行微生物识别.

主要方法:

进行了一项临床研究,共有40名参与者 (20名固定假肢,20名健康对照).
收集了来自不同组的60个supragingival斑块样本:金属陶冠,陶冠和天然牙.
采用了16S rDNA高通量测序和生物信息分析 (Qiime,R,PICRUSt2).

主要成果:

与天然牙相比,固定假牙上的上斑块表现出不同的微生物组成和多样性.
在假牙上发现了高水平的牙周病原体,如 Porphyromonas gingivalis.
功能分析表明,假肢上的微生物代谢更活跃,与牙周病的发展有关.
陶皇冠显示微生物群与天然牙更相似,而不是金属陶皇冠.

结论:

固定假牙和自然牙之间的supragingival斑块微生物群存在显著差异.
陶皇冠对斑块微生物组结构的影响比金属陶皇冠要小.
固定修复的材料选择对于保护围牙周围的牙周健康至关重要.

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