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生物流体衍生的外体LncRNAs:它们在肥胖和相关并发症中的潜力

Ebenezeri Erasto Ngowi^1,2,3, Tuyan Lu¹, Qing Liu¹

¹Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China.

|January 8, 2025

概括

肥胖和相关疾病在全球范围内正在上升. 外体长非编码RNAs (exo-lncRNAs) 作为生物标志物和治疗点,有望用于管理代谢障碍和改善器官间通信.

科学领域:

生物化学生物化学
分子生物学分子生物学
内分泌学在内分泌学.

背景情况:

自20世纪70年代以来,全球肥胖率增加了三倍,反映了2型糖尿病,癌症和心血管疾病的增加.
目前的肥胖和代谢性疾病疗法有低于最佳的反应率,突显了需要新策略的需要.
器官间通信 (IOC) 在代谢障碍中至关重要,外体通过运输分子调解这种通信.

研究的目的:

审查外体长非编码RNAs (exo-lncRNAs) 在肥胖症和相关代谢疾病中的诊断和治疗潜力.
强调 exo-lncRNAs 在器官间通信 (IOC) 和疾病进展中的作用.
为了确定未来研究基于外型ncRNA的代谢性疾病管理的有希望的途径.

主要方法:

文献综述侧重于外体RNA,特别是长非编码RNA (lncRNA).
对研究生物流体 (血液,尿液等) 中的exo-lncRNA的研究分析. 以及它们与代谢参数的相关性.
综合证据对外o-lncRNAs在IOC和代谢途径调节中的作用.

主要成果:

外体RNA,包括外体lncRNA,在各种疾病中发生变化,存在于多种生物流体中,表明具有诊断潜力.
异位lncRNAs的变化与具有代谢相关条件的患者的代谢参数相关.
异种lncRNA与关键代谢途径组件相互作用,这表明它们在疾病发病过程中起着重要作用.

结论:

外体lncRNAs作为肥胖和相关代谢障碍的诊断生物标志物具有显著的前景.
向exo-lncRNAs为改善代谢健康和器官间通信提供了一个潜在的治疗策略.
进一步的研究至关重要,以阐明外界ncRNAs的精确功能,并开发临床应用.

关键词:

生物流体是一种生物流体.外基因组是外基因组的组成部分.长长的非编码RNAs.肥胖和相关疾病.

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