在代谢功能障碍相关的脂肪肝疾病中的谷氨酸氧化还原恒温的改变:系统性审查
Lucia Cesarini1, Flavia Grignaffini1, Anna Alisi1
1Research Unit of Genetics of Complex Phenotypes, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Antioxidants (Basel, Switzerland)
|January 8, 2025
概括
低分子量硫醇,如谷氨,与代谢功能障碍相关的脂肪性肝病 (MASLD) 有关. 增加的硫醇水平可能与MASLD的严重程度相关,但需要标准化的测量方法.
科学领域:
- 生物化学 生物化学
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 低分子量 (LMW) 硫醇,特别是谷氨,在氧化还原恒温和疾病病原发生过程中至关重要.
- 肝脏在醇代谢中的中心作用使其易受氧化还原失衡的影响,导致代谢功能障碍相关的脂肪性肝病 (MASLD) 的肝损伤.
- 细胞和细胞外LMW硫醇的升高可能与MASLD的严重程度有关.
研究的目的:
- 系统地审查最近关于MASLD中LMW醇水平的文献.
- 分析体内,体外和人类研究中关于MASLD中的LMW醇的发现.
- 确定挑战,并提出LMW醇研究在MASLD的未来方向.
主要方法:
- 系统的文献审查遵循PRISMA 2020指南.
- 在PubMed和Scopus数据库中进行的搜索.
- 对165项涉及动物,细胞和人类模型的研究进行了定性分析.
主要成果:
- 大多数审查的研究使用动物和细胞模型,更少的研究使用人类生物流体.
- 在用于样本处理和LMW硫醇水平测量的方法中观察到显著的异质性.
- 方法的这种变异性阻碍了在MASLD中确定LMW硫醇的可靠诊断截止值.
结论:
- LMW硫醇与MASLD的发病和严重程度有关.
- 目前的研究表现出相当大的方法异质性,限制了临床适用性.
- 标准化LMW硫醇分析和测量对于推动MASLD研究和诊断至关重要.
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