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库库比塔佩波 (Cucurbita pepo) 的化学特征和有前途的应用 L. Flowers 花

Ritamaria Di Lorenzo¹, Luigi Castaldo¹, Raffaele Sessa²

¹Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano, 49, 80131 Naples, Italy.

Antioxidants (Basel, Switzerland)

|January 8, 2025

概括

可食用的南瓜 (Cucurbita pepo L.) 花,富含抗氧化剂,显示出对皮肤健康的重大潜力. 这项研究揭示了它们对抗衰老和紫外线损伤的能力,改善皮肤水分和外观.

科学领域:

植物化学植物化学
皮肤病学皮肤病学
化品科学化品科学

背景情况:

可食用花朵越来越多地被认为是生物活性化合物.
Cucurbita pepo L. (CpL) 的花中含有丰富的多和胡卜素.
对于皮肤健康的CpL花的应用尚未得到充分研究.

研究的目的:

分析CpL花提取物 (CpLfe) 的多和胡卜素含量.
为了评估CpLfe的抗氧化和抗衰老特性,在体外和体内.
调查CPLfe对皮肤水分,屏障功能和衰老标志物的影响.

主要方法:

先进的UHPLC-Q-Orbitrap HRMS和HPLC-DAD用于植物化学分析.
DPPH,ABTS和FRAP测定用于抗氧化活性评估.
在体外对HaCaT细胞 (ROS减少,MMP-1表达) 和基因表达分析 (AQP3,CERS) 的研究.
在35-55岁的女性中进行的安慰剂对照随机临床试验.

主要成果:

CpLfe显示出显著的抗氧化活性.
CpLfe减少了HaCaT细胞中的细胞内ROS,并保护其免受UVB诱导的损伤.
CpLfe上调皮肤水分和屏障功能基因.
临床试验显示改善了皮肤水分,减少了纹,增加了原蛋白.

结论:

CpL花是用于皮肤应用的生物活性化合物的宝贵来源.
CpLfe有效地改善了皮肤老化和光衰老特征.
CpL花代表了一种有前途的天然成分,用于化品和皮肤病治疗.

关键词:

黄瓜 (Cucurbita pepo) 是一种类植物.在Q-Exactive中使用.胡卜素是一种胡卜素.摄影保护的照片保护.聚醇是一种多醇.可持续性可持续性的可持续性

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