素纳米颗粒的配方,特征和抗氧化特性 含有来自橄树的化合物
Ilaria Fierri1, Roberto Chignola1, Chiara Stranieri2
1Department of Biotechnology, University of Verona, 37134 Verona, Italy.
Antioxidants (Basel, Switzerland)
|January 8, 2025
概括
橄果类被封装成纳米颗粒,以增强抗氧化剂的输送. 这种方法提升了橄副产品的价值,为营养药物应用创造了稳定的纳米颗粒.
科学领域:
- 食品科学 食品科学 食品科学
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 橄的化合物,包括氧醇 (OH-Tyr) 和醇 (Tyr),具有重要的抗氧化特性,对健康有益.
- 这些有价值的化合物在特级初橄油 (EVOO) 中稀缺,但在橄果汁 (OP) 中丰富,这是石油生产的副产品.
研究的目的:
- 从橄果汁 (OP) 中提取和封装化合物到奇多三聚酸纳米颗粒 (NP).
- 为了提高这些抗氧化的稳定性和传递,使用离子热凝冷化方法用于营养药物应用.
主要方法:
- 从OP中提取了化合物,并通过离子转化凝将其封装到奇多三聚酸盐NP中.
- 用冷化来稳定NP,曼尼托和马尔托德丁DE 19 (MD-19) 被评估为冷保护剂.
- 分析了粒子大小,多分散度指数 (PDI),泽塔潜力和封装效率 (EE%).
主要成果:
- 封装过程产生了单分散,阴离子NP (尺寸:229纳米,PDI:0.21,z-电位:33mV) 具有高EE% (64-65%) 的总含量和OH-Tyr + Tyr.
- 用0.7%的MD-19冷干燥被证明是最佳的,在再水后保持NP单分散性.
- 由此产生的NP在无细胞试验和氧化应激的THP-1细胞模型中都显示出显著的抗氧化能力.
结论:
- 离子体凝冷化方法有效地封装和稳定了抗氧化剂橄末类在三聚酸纳米颗粒中.
- 这种方法为提升橄副产品的价值和开发新型营养药品提供了一个有希望的战略.
- 开发的纳米颗粒显示出提供促进健康的橄类的潜力,改善它们对环境和化学压力的抵抗力.
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