乳清蛋白缩基辅酶Q10纳米颗粒的物理化学特性,抗氧化能力和生物可用性
Yuxue Sun1, Jiafei Liu1, Xiaowen Pi1
1College of Food Science, Northeast Agricultural University, Harbin 150030, China.
Antioxidants (Basel, Switzerland)
|January 8, 2025
概括
乳清蛋白纳米颗粒有效封装辅酶Q10 (CoQ10),显著提高其抗氧化能力和生物可用性. 这种输送系统克服了CoQ10的作用.
科学领域:
- 食品科学与技术 食品科学与技术
- 生物技术是生物技术.
- 营养保健品 营养保健品
背景情况:
- 辅酶Q10 (CoQ10) 是一种重要的抗氧化剂,由于水溶性差和生物可用性低,应用有限.
- 开发有效的输送系统对于增强CoQ10的治疗潜力至关重要.
研究的目的:
- 使用乳清蛋白缩物 (WPC) 和聚合 WPC (PWPC) 来创建和描述载有 CoQ10 的纳米粒子.
- 评估这些新型CoQ10输送系统的物理化学性质,抗氧化能力和生物可用性.
主要方法:
- 使用WPC和PWPC的纳米颗粒制剂,蛋白质与CoQ10的比例不同.
- 通过粒子大小分析,差分扫描热度计,里埃变换红外光谱学和传输电子显微镜进行表征.
- 评估抗氧化能力,模拟胃肠道消化和体内生物可用性.
主要成果:
- WPC和PWPC形成的纳米粒子大小在241-331nm之间.
- 通过疏水相互作用 (以及WPC中的键) 成功嵌入了CoQ10.
- PWPC纳米颗粒的抗氧化能力略高;这两种系统都显著提高了CoQ10的生物可用性 (约. 增加了7.5倍).
结论:
- WPC和PWPC作为有效的携带者,可提供Q10.
- 这些基于乳清蛋白的纳米颗粒显著改善了CoQ10的抗氧化特性和生物可用性.
- 开发的系统为提高CoQ10和类似生物活性化合物的疗效提供了一个有希望的策略.
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