2型糖尿病及其并发症中的相关血清内质网膜压力生物标志物:系统性审查和元分析
José Rafael Villafan-Bernal1,2,3, Francisco Barajas-Olmos1, Iris Paola Guzmán-Guzmán4
1Immunogenomics and Metabolic Diseases Laboratory, Instituto Nacional de Medicina Genómica, SS, Mexico City 14610, Mexico.
Antioxidants (Basel, Switzerland)
|January 8, 2025
概括
在2型糖尿病 (T2D) 中,六个内质网膜压力 (ERS) 生物标志物升高. 这些ERS标记与T2D患者的血糖控制,胰岛素抵抗和β细胞功能相关.
科学领域:
- 内分泌学和新陈代谢学
- 分子生物学分子生物学
- 生物标志物发现发现
背景情况:
- 细胞内膜网膜应激 (ERS) 是细胞对诸如高血糖等压力因素的反应.
- 在2型糖尿病 (T2D) 中持续改变的ERS的特定血清生物标志物仍然不完全理解.
- 确定可靠的ERS生物标志物对于了解T2D病原和并发症至关重要.
研究的目的:
- 为了识别在T2D中持续改变的血清ERS生物标志物.
- 研究这些生物标志物与T2D中的代谢和人类学变量之间的相关性.
- 评估ERS生物标志物与T2D并发症的关联.
主要方法:
- 按照PRISMA和MOOSE指南进行系统审查和元分析.
- 包括22项研究,涉及11,953名受试者 (2,224名2型糖尿病患者).
- 使用纽卡斯尔-太华尺度评估偏差风险;使用随机效应模型进行元分析.
主要成果:
- 与对照组相比,在T2D患者中观察到高温冲击蛋白70 (HSP70) 和分泌素的血清水平.
- 在T2D中也发现了更高的氧素-1, -2, -4,和 -6的血清水平.
- 秘素,PRX4和HSP70与血糖控制 (HbA1c,FPG),胰岛素抵抗 (HOMA-IR) 和β细胞功能 (HOMA-B) 有显著的相关性.
结论:
- 在T2D中,六个血清ERS生物标志物 (HSP70,秘,PRX1,PRX2,PRX4,PRX6) 在T2D中持续升高.
- 这些生物标志物与关键的代谢参数相关,包括血糖控制和胰岛素耐药性.
- 需要进一步的研究来探索血清ERS生物标志物的预后价值在T2D并发症中.
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