在大多数肌痛性脑筋炎/慢性疲劳综合征患者中,心脏输出-脑血流关系异常,在倾斜测试期间心率和血压反应正常
C Linda M C van Campen1, Freek W A Verheugt2, Peter C Rowe3
1Stichting Cardio Zorg, Kraayveld 5, 1171 JE Badhoevedorp, The Netherlands.
Healthcare (Basel, Switzerland)
|January 8, 2025
概括
大多数肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 患者在倾斜测试期间表现出异常的大脑血流 (CBF) 和心脏输出 (CO). 这表明ME/CFS中潜在的内皮功能障碍,影响临床管理.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 生理学 生理学 生理学
背景情况:
- 静态不耐受性常见于肌痛性脑膜炎/慢性疲劳综合征 (ME/CFS),与大脑血流 (CBF) 减少有关.
- 在健康个体中,心脏输出 (CO) 显著影响CBF调节.
- 之前的研究表明,ME/CFS患者在倾斜测试期间,CO和CBF的减少类似.
研究的目的:
- 在ME/CFS患者中研究CBF和CO之间的关系.
- 确定这种关系是否在ME/CFS患者和健康对照人群 (HCs) 之间有所不同.
主要方法:
- 对534名ME/CFS患者和49名HC患者的倾斜测试数据进行了回顾性分析.
- 测量包括心率 (HR),血压 (BP),CBF,CO和潮结束时的PCO2 (PETCO2).
- 使用多普勒超声波测量CBF和CO,重点关注倾斜时HR和BP反应正常的患者.
主要成果:
- 91%的ME/CFS患者在倾斜测试期间显示CO和CBF异常减少.
- 在这些患者中,CO降低强烈预测CBF降低 (1:1关系).
- 在CBF变化中,潮末的PCO2降低起到了很小的作用.
结论:
- 根据倾斜测试反应,确定了两个不同的ME/CFS患者组.
- 大多数 (91%) 患者表现出异常的CO和CBF减少,这表明补偿性血管扩张受损.
- 这表明在大多数ME/CFS患者中存在潜在的内皮功能障碍,这对治疗有影响.
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