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洞察肠道微生物组与固体瘤中的免疫检查点抑制剂之间的关系

Sona Ciernikova¹, Aneta Sevcikova¹, Maria Novisedlakova²

¹Department of Genetics, Cancer Research Institute, Biomedical Research Center of the Slovak Academy of Sciences, Dubravska Cesta 9, 845 05 Bratislava, Slovakia.

|January 8, 2025

概括

肠道微生物组显著影响癌症免疫疗法的有效性和副作用. 通过饮食或益生菌调节肠道细菌可以提高治疗结果并降低患者的毒性.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
微生物学微生物学

背景情况:

免疫检查点抑制剂 (ICI),如抗CTLA-4和抗PD-1/PDL-1,已经彻底改变了癌症治疗.
然而,ICI的有效性和安全性在患有固体瘤的患者之间有很大差异.
人们越来越认识到肠道微生物组在影响这些变异中的作用.

研究的目的:

审查肠道微生物组在调节免疫检查点封锁的有效性和毒性方面的关键作用.
探索微生物组组成如何影响抗瘤免疫反应和不良事件.
讨论基于微生物组的干预措施,以优化癌症免疫治疗.

主要方法:

对研究肠道微生物组和ICI治疗的文献综述.
对特定细菌菌株,失生症和免疫媒介毒性研究的分析.
检查针对肠道微生物组的干预措施,包括益生菌,益生菌,FMT和饮食.

主要成果:

肠道微生物组的组成与患者对免疫治疗的反应有关.
特定的细菌可以促进抗瘤免疫力,而失生菌可能会增加诸如结肠炎之类的风险.
微生物组调节策略在提高ICI有效性和降低毒性方面表现有前途.

结论:

肠道微生物组是ICI治疗结果的关键因素.
针对微生物组为个性化癌症治疗策略提供了潜力.
将免疫疗法与微生物干预相结合可能会改善耐药患者的生存率.

关键词:

癌症治疗治疗治疗癌症便微生物群移植免疫检查点抑制剂免疫检查点抑制剂益生菌是一种益生菌.固体瘤是一种固体瘤.肠道的微生物群.

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