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相关概念视频

Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Regulation of Hematopoietic Stem Cells01:01

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis
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类固醇和恶性瘤增加局部肝酶,减少骨质母细胞活性标记物在骨组织的微循环.

Keren Asayag1,2, Eli Peled2,3, Mai Assalia1,2

  • 1Thrombosis and Hemostasis Unit, Rambam Health Care Campus, Haifa 3109601, Israel.

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概括
此摘要是机器生成的。

类固醇和恶性瘤激活骨中的血液凝固,减少骨建设活动并增加骨折风险. 肝酶抑制剂可能有助于预防骨疼痛和骨折.

关键词:
骨头 骨头 骨头 骨头肝酶的使用方法恶性瘤是一种恶性瘤.微循环是一种微循环.类固醇类固醇是什么血栓形成的原因是血栓形成.

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科学领域:

  • 生物化学 生物化学
  • 在瘤学瘤学.
  • 整形外科 整形外科 整形外科

背景情况:

  • 类固醇和恶性瘤激活凝血并诱导骨质流失,骨折和疼痛.
  • 肝酶可以增强血液静止,血管生成,转移和炎症.

研究的目的:

  • 评估类固醇和恶性瘤对凝血因子和骨质细胞在骨组织中的活性的影响.
  • 调查肝酶在这些过程中的作用.

主要方法:

  • 在体外研究中,使用暴露于脱皮和恶性介质的骨质母细胞和HUVEC.
  • 在体内研究中,小鼠接受了dexacort治疗.
  • 从患有骨转移,AVN,骨关节炎和对照患者的骨活检分析.

主要成果:

  • 在细胞中,dexacort和恶性介质增加了肝酶水平,并降低了性酸酶 (ALKP).
  • 肝酶衍生的可以调节这些效应.
  • 小鼠和人类的骨活检显示肝酶,凝血因子 (TF,TFPI,TFPI-2,血栓,纤维素) 和血管扩张,骨质细胞标记物 (骨素,ALKP) 减少.

结论:

  • 类固醇和恶性瘤激活骨微循环凝结,并损害骨质细胞活性.
  • 肝酶在这些病理变化中起着关键作用.
  • 肝酶抑制剂需要进一步研究,以治疗骨折和疼痛.