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在非小细胞肺癌管理中的上皮-半机关过渡:机遇和挑战

Yunyao Ye¹, Shanxun Yu¹, Ting Guo²

¹Department of Oncology, Taizhou People's Hospital Affiliated to Nanjing Medical University, Taizhou 225300, China.

|January 8, 2025

概括

表皮-介质细胞过渡 (EMT) 驱动非小细胞肺癌 (NSCLC) 转移和免疫抑制. 抑制EMT可以通过向瘤生长和进展来提高NSCLC治疗疗效.

科学领域:

在瘤学瘤学.
癌症生物学癌症生物学
免疫学免疫学免疫学

背景情况:

非小细胞肺癌 (NSCLC) 是全球癌症死亡的主要原因.
尽管治疗方面取得了进展,但导致转移的耐药性仍然是死亡的主要原因.
表皮-介质细胞过渡 (EMT) 是癌细胞入侵和转移的关键驱动因素.

研究的目的:

审查EMT在NSCLC转移中的作用.
阐明EMT对瘤免疫微环境的影响.
探索EMT抑制作为NSCLC的治疗策略.

主要方法:

在NSCLC中对EMT的研究的文献综述.
分析EMT对瘤进展和免疫逃避的影响.
探索与EMT相关的潜在治疗目标.

主要成果:

EMT促进NSCLC细胞的侵入性和转移.
EMT有助于免疫抑制瘤微环境.
抑制EMT是一种有希望的策略,可以克服治疗耐药性.

结论:

在NSCLC的进展和不良预后中,EMT是关键因素.
向EMT可以提供一种多步骤的方法来抑制瘤生长并提高治疗效率.

关键词:

表皮介质介质的过渡.免疫检查点抑制剂免疫检查点抑制剂转移转移转移转移非小细胞肺癌的肺癌.瘤免疫的微环境

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