晚期酒精暴露不会加剧老年依赖的小鼠空间记忆和大脑TFEB活动的减少
Hao Chen1, Kaitlyn Hinz1, Chen Zhang1
1Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS 66160, USA.
Biomolecules
|January 8, 2025
概括
老龄化显著损害大脑自和空间记忆,比酒精消费更严重. 在老鼠中,慢性酒精摄入并没有恶化与年龄相关的认知衰退或自减弱.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
- 衰老研究研究 衰老研究
背景情况:
- 酒精消费对阿尔茨海默病 (AD) 风险的影响尚不清楚,自可能会调解这种联系.
- 自,对细胞平衡至关重要,由转录因子EB (TFEB) 调节,影响溶解体和自相关的基因表达.
研究的目的:
- 调查慢性饮酒是否会加剧TFEB介导的溶酶体生物发生和认知功能的与年龄相关的下降.
- 为了确定酒精对大脑TFEB活动和年轻小鼠与老年小鼠的自的影响.
主要方法:
- 暴露年轻和老年小鼠的酒精养模式.
- 对生物化学,转录组,组织学和行为终点的评估,包括TFEB活性和自标志物 (SQSTM1/p62,LC3-II).
- 使用莫里斯水和巴恩斯迷宫任务对空间记忆的评估.
主要成果:
- 在年轻小鼠中,酒精降低了海马体TFEB,增加了自标志物和化Tau.
- 老年小鼠的海马TFEB活性低于年轻小鼠;酒精并没有加剧与年龄相关的衰退.
- 老龄化影响空间记忆的获取比酒精消费更大,酒精在老年小鼠中显示出最小的负面甚至微小的积极影响.
结论:
- 老龄化导致大脑自流量和空间记忆缺陷的显著减少,而不是酒精消费.
- 慢性酒精暴露不会加剧TFEB介导的自或空间记忆的与年龄相关的下降.
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