增长差异化因子15作为心胸外科重症监护病房风险分层的生物标志物
Ricardo Ferreira1, Tiago R Velho1,2,3, Rafael Maniés Pereira1,2,4
1Department of Cardiothoracic Surgery, Hospital de Santa Maria, Unidade Local de Saúde de Santa Maria, 1649-028 Lisbon, Portugal.
心脏手术后,生长差异化因子15 (GDF15) 增加,在6小时达到峰值. 较高的GDF15水平表明术后并发症的风险更高,如急性损伤和长时间的支持.
科学领域:
- 在心血管外科手术中发现生物标志物
- 炎症和压力反应途径的炎症和压力反应途径.
背景情况:
- 增长分化因子15 (GDF15) 是一种与压力和炎症相关的新兴生物标志物.
- 它在预测心脏手术后早期术后并发症方面的作用尚不清楚.
研究的目的:
- 在接受大动脉置换手术的患者中描述术后的GDF15形状.
- 评估GDF15水平与短期术后结果之间的关联.
主要方法:
- 在手术前和手术后1,6,12,24和48小时测量血清GDF15水平.
- 评估了与心肺绕道,大动脉十字时间和临床结果的相关性.
主要成果:
- 手术后GDF15水平显著增加,在6小时达到峰值.
- 升高的GDF15与更长的绕道和十字时间相关.
- 较高的GDF15水平与急性损伤,延长的血液动力学支持,增加的通风时间和更长的ICU停留有关.
结论:
- 手术后的GDF15水平在进行大动脉置换手术后显著上升.
- GDF15是风险分层和指导心脏手术患者治疗决策的潜在生物标志物.
- 高GDF15与不良的短期结果有关,包括AKI和长期支持.
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