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口服的乳杆菌菌株调节膜巨细胞,改善对呼吸道超级感染的保护

Leonardo Albarracin¹, Stefania Dentice Maidana¹, Kohtaro Fukuyama²

¹Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), San Miguel de Tucumán 4000, Argentina.

|January 8, 2025

概括

口服乳酸菌株Lacticaseibacillus rhamnosus CRL1505和Lactiplantibacillus plantarum MPL16通过增强膜巨细胞中训练的免疫力来预防二次呼吸道感染.

科学领域:

免疫学免疫学免疫学
微生物学微生物学
呼吸系统健康呼吸系统健康

背景情况:

口服的免疫调节乳酸菌可增强呼吸道免疫力,对抗主要感染.
这些乳酸菌对呼吸道超级感染的疗效在很大程度上仍未被探索.

研究的目的:

评估特定乳酸菌菌株对二次呼吸道感染的保护作用.
阐明乳酸菌介导的防治呼吸道超级感染的机制.

主要方法:

婴儿小鼠被口服 Lacticaseibacillus rhamnosus CRL1505 或 Lactiplantibacillus plantarum MPL16. 这些药物.
随后,在TLR3激活或RVS感染后,小鼠受到二次肺炎球菌感染的挑战.
评估了免疫反应,包括干扰素的产生,细胞因子平衡,细菌负载和肺损伤.

主要成果:

乳球菌的使用降低了对二次肺炎球菌感染的易感性.
治疗增强了呼吸干扰素的产生和调节的细胞因子平衡.
细菌复制和肺部损伤减少,表明宿主防御得到改善.
观察到长期的保护,由受刺激的训练膜巨细胞介导.

结论:

特定的乳酸菌株提供了对二次呼吸道细菌挑战的保护.
这种保护与通过肠肺轴刺激训练有素的膜巨细胞有关.
这些发现凸显了口服乳酸菌在治疗呼吸道超级感染方面的潜力.

关键词:

乳酸酶ibacillus rhamnosus CRL1505的使用情况膜细胞巨细胞.益生菌的乳酸菌呼吸道免疫力呼吸道免疫力超级感染是一种超级感染.

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