动态的PK/PD感染模型用于开发和优化抗菌方案:叙述性审查
Yalew M Wale1,2, Jason A Roberts1,3,4,5, Fekade B Sime1
1Centre for Clinical Research (UQCCR), Faculty of Medicine, The University of Queensland, Brisbane, QLD 4029, Australia.
Antibiotics (Basel, Switzerland)
|January 8, 2025
概括
动态的体外感染模型模拟了人类的抗微生物暴露,这对于预测治疗成功至关重要. 这些模型有助于优化药物剂量和开发对抗耐药病原体的策略.
科学领域:
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 抗菌活性受人类度-时间特征的影响.
- 临床前模型必须模仿人类的药理动力学/药理动力学 (PK/PD) 以实现可翻译性.
- 动态的体外感染模型对于准确的抗微生物药物开发至关重要.
研究的目的:
- 对抗微生物药物开发进行动态体外感染模型的审查.
- 讨论它们的设置,原则和应用.
- 突出它们在优化抗微生物药物治疗方案中的作用.
主要方法:
- 对常用的动态体外感染模型 (例如空心纤维,生物膜) 的审查.
- 对模拟抗微生物药物动力学概况的数学方法的概述.
- 讨论串行和并行 in vitro 系统配置.
主要成果:
- 动态体外模型为初始剂量方案提供可靠的PK/PD数据.
- 这些模型有助于优化现有的抗微生物治疗方法,特别是针对耐药性.
- 它们产生预测临床疗效的数据.
结论:
- 动态的体外感染模型有效地复制人类-微生物-药物相互作用.
- 这些模型对于开发新的抗微生物药物和治疗策略至关重要.
- 它们对于对抗抗微生物药物耐药性特别有价值.
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