基因与生活方式相互作用对学生肥胖的影响
Emiliya S Egorova1, Kamilla K Aseyan1, Elvina R Bikbova1
1Laboratory of Genetics of Aging and Longevity, Kazan State Medical University, 420012 Kazan, Russia.
Genes
|January 8, 2025
概括
遗传倾向和生活方式选择显著影响肥胖风险. 具有更高遗传易感性的个体在受到特定环境和生活方式因素的影响时更容易增加体重.
科学领域:
- 遗传学和环境健康
- 肥胖问题研究研究
- 公共卫生 公共卫生
背景情况:
- 肥胖是一个复杂的全球健康挑战,由遗传和环境影响驱动.
- 了解这些因素之间的相互作用对于开发有效的干预措施至关重要.
- 由于共同的环境因素,大学生代表了研究这些关系的关键人口.
研究的目的:
- 研究遗传倾向和生活方式因素对肥胖风险的综合影响.
- 探索影响身体质量指数 (BMI) 的潜在基因环境相互作用.
- 确定与年轻成年人肥胖风险增加相关的特定遗传变异和生活方式行为.
主要方法:
- 招募了658名大学生 (531名女性,127名男性).
- 参与者进行了人体测量,基因查,并填写了关于生活方式和睡眠质量的问卷.
- 计算了身体质量指数 (BMI),并使用遗传数据推导出多基因风险得分.
主要成果:
- 基于七种遗传变异的多基因风险评分解释了8.3%的BMI变异 (p < 0.0001).
- 生活方式因素,包括饮食,体力活动和睡眠,占BMI变异的7.8% (p < 0.0001).
- 基因与环境的相互作用对BMI变异有15%的显著贡献 (p < 0.0001).
结论:
- 遗传倾向在肥胖风险中起着重要作用.
- 生活方式条件可以加剧或减轻对肥胖的遗传易感性.
- 需要针对性干预,同时考虑遗传和生活方式因素,以解决肥胖问题.
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