心血管疾病和阿尔茨海默氏症之间的关系是遗传的吗? 一个范围广泛的审查
Anni Moore1, Marylyn D Ritchie1,2,3
1Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Genes
|January 8, 2025
概括
心血管疾病 (CVD) 和阿尔茨海默病 (AD) 具有共同的遗传联系和生物途径,增加了这两种疾病的风险. 了解这些重叠,特别是脂质代谢和血压,是管理与衰老相关疾病的关键.
科学领域:
- 遗传学和衰老研究研究
- 神经科学是一个神经科学.
- 心脏病学 心脏病学
背景情况:
- 心血管疾病 (CVD) 和阿尔茨海默氏病 (AD) 在老年人群中经常同时发生.
- 流行病学数据表明,心血管疾病和AD风险之间存在双向关系.
- 这种并发症的确切遗传基础仍然不完全理解.
研究的目的:
- 进行对心血管疾病和AD之间已识别的重叠遗传学的范围审查.
- 在个体基因和途径层面检查共享的遗传风险.
- 综合当前关于这些普遍的衰老疾病之间的遗传关系的证据.
主要方法:
- 在PubMed和Scopus数据库的系统文献搜索 (1990年至2024年10月).
- 遵守PRISMA-ScR指导方针进行范围审查.
- 纳入标准侧重于使用统计方法分析心血管疾病和AD之间的遗传关系的研究.
主要成果:
- 从2918个初始结果中,选出了274篇文章,分为共享的遗传风险和机制.
- 像APOE,PSEN1和PSEN2这样的基因在AD和CVD上都表现出影响.
- 关键的共享途径包括脂质代谢,血压调节和血脑屏障 (BBB) 完整性.
结论:
- 具有高透性的家族基因可以同时提高心血管疾病和AD的风险.
- 脂肪代谢,血压控制和BBB功能等更广泛的途径的调节失调显著导致AD和CVD的并发症和进展.
- 进一步的研究需要多样化的种群和纵向数据来充分阐明遗传贡献.
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