用提取物减轻氧化应激并促进细胞寿命
Menna-Allah E Abdelkader1,2, Hatungimana Mediatrice1,3, Dongmei Lin1
1China National Engineering Research Center of Juncao Technology, College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Foods (Basel, Switzerland)
|January 8, 2025
概括
像Agaricus bisporus和Hericium erinaceus这样的药用显示出强大的抗氧化和抗衰老功效. 提取物促进细胞增殖,DNA合成,并减少氧化应激,这表明天然的抗衰老潜力.
科学领域:
- * 菌类学和生物化学
- * 细胞生物学和衰老研究
- * * 自然产品化学 自然产品化学
背景情况:
- *由自由基引起的氧化应激会加速衰老,并导致健康问题.
- * 药用和食用因其潜在的促进健康的特性而得到认可.
- *了解的抗氧化和抗衰老机制对于开发自然干预措施至关重要.
研究的目的:
- * 评估四种真菌种的抗氧化和抗衰老潜力:光皮真菌,黑真菌,斑马真菌,和Agaricus bisporus.
- * 评估提取物对细胞与衰老相关的细胞过程的影响.
- * 研究这些提取物的免疫调节和抗炎活性.
主要方法:
- *使用DPPH,ABTS和降低功率测试评估的抗氧化活性.
- *对D-银糖诱导的人体皮肤纤维细胞 (HSF) 细胞的抗衰老效果进行了评估.
- *测量了细胞增殖,细胞循环进展,DNA合成,DNA损伤和反应性氧物种 (ROS) 水平.
- *免疫调节效应通过分析INTERLEUKIN (IL)-2,IL-4和IL-6的表达来评估.
主要成果:
- *所有测试的提取物都表现出显著的抗氧化和抗衰老特性.
- * Agaricus bisporus 提取物 (0.03 毫克/毫升) 促进了87%的细胞增殖.
- * Hericium erinaceus提取物 (0.03毫克/毫升) 增强了细胞周期进展和DNA合成.
- *提取物减少了DNA损伤和ROS水平,减轻了氧化应激.
- *提取物通过上调IL-2/IL-4和降低IL-6来显示免疫调节作用.
结论:
- *提取物具有显著的抗氧化和抗衰老能力,可以防止氧化应激.
- * 这些天然剂可以通过增强细胞增殖,细胞循环进展和DNA合成来促进细胞健康.
- * 免疫调节和抗炎作用进一步支持在促进整体健康方面的潜力.
- *需要对特定生物活性化合物和体内疗效进行进一步的研究.
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