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商业海洋油补充剂中脂肪酸生物可访问性的比较分析:一个体外综合分析研究
Thomas Montebugnoli1, Giorgia Antonelli1, Elena Babini1,2
1Department of Agricultural and Food Sciences (DISTAL), University of Bologna, 47521 Cesena, Italy.
Foods (Basel, Switzerland)
|January 8, 2025
概括
来自鱼和Calanus finmarchicus的海油补充剂由于脂类差异而表现出不同的脂肪酸释放. 这影响了必需的欧米茄-3长链多不和脂肪酸 (n-3 LC-PUFA) 的吸收和有效性.
科学领域:
- 营养科学 营养科学
- 海洋生物学 海洋生物学
- 生物化学 生化学
背景情况:
- 海洋油补充剂的目的是增加摄入的omega-3长链多不和脂肪酸 (n-3LC-PUFA).
- 来自不同海洋来源 (鱼,,动物浮游生物) 油中的脂类分布影响脂肪酸的生物可访问性.
- 了解脂肪酸释放对于优化补充剂疗效至关重要.
研究的目的:
- 评估和比较各种海洋油补充剂体内释放的自由脂肪酸 (FFAs).
- 调查油源和脂质组成对脂肪酸生物可访问性的影响.
- 为了将FFA释放与n-3LC-PUFA的潜在吸收和有效性相关联.
主要方法:
- 在实验室中消化了四种商业海洋油补充剂 (鱼,,Calanus finmarchicus).
- 使用薄层染色学与火焰电离检测 (TLC-FID) 释放脂肪酸的分析.
- 使用质子核磁共振 (1H-NMR) 光谱学阐明脂类和脂肪酸分布的结构.
主要成果:
- 在模拟消化后的FFA释放因海洋石油来源而有显著差异.
- 富含 Ester 的 Calanus 油具有最低的 FFA 释放率.
- 脂质分成不同的类别,而不是封装,是FFA释放的主要决定因素.
结论:
- 海洋油的来源及其脂类组成极大地影响了n-3 LC-PUFA的生物可访问性.
- 某些油 (例如,卡兰) 的低FFA释放可能会影响omega-3s的吸收和有效性.
- 这些发现可能有助于解释使用海洋油补充剂的临床研究中观察到的不一致性.
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