在SARS-CoV-2感染后,患有先前存在的基本的患者的长期结果
Rachel Pakan1, Roham Hadidchi1, Yousef Al-Ani1
1Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA.
Diagnostics (Basel, Switzerland)
|January 8, 2025
概括
在基本震 (ET) 患者中,COVID-19显著增加了长期不良健康结果的风险,包括心血管事件和新发精神健康问题. 然而,该研究没有发现与COVID-19相关的全因死亡风险增加.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 心脏病学 心脏病学
背景情况:
- 基本震 (ET) 是一种常见的神经疾病.
- COVID-19已与各种患者群体的不良结果有关.
- COVID-19对基本震患者的具体影响尚不清楚.
研究的目的:
- 为了调查COVID-19感染后基本震患者的长期临床结果.
- 为了比较有和没有COVID-19病史的基本震患者的不良健康事件.
主要方法:
- 从2016年1月到2023年7月,对1074名精髓震患者进行了回顾性研究.
- 具有和没有SARS-CoV-2感染的ET患者之间的结局的比较.
- 分析包括主要不良心血管事件 (MACE),睡眠障碍,疲劳,呼吸不良,跌倒,焦虑,抑郁和死亡率,以及调整后的危险比率 (aHR).
主要成果:
- 患有COVID-19的ET患者有更高的2型糖尿病,抑郁症和焦虑症.
- COVID-19与MACEs (aHR=2.39),新发睡眠障碍 (aHR=2.12),疲劳 (aHR=1.83),呼吸障碍 (aHR=1.98),首次跌倒 (aHR=4.76),新发焦虑 (aHR=3.66) 和新发抑郁症 (aHR=2.38) 的风险增加有关.
- 在ET患者中,COVID-19和全因死亡率之间没有发现显著的关联.
结论:
- COVID-19 感染显著提高了基本震患者多种长期不良健康结果的风险.
- 这些风险包括心血管事件,神经和心理障碍,以及降落风险增加.
- COVID-19似乎不会增加患有基本震的个体全因死亡的风险.
相关概念视频
Parkinson's Disease: Treatment
215
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
215
Parkinson's Disease: Overview
472
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
472
Myasthenia Gravis: Overview and Treatment
1.2K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.2K
Skeletal Muscle Relaxants: Adverse Effects
334
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
Unlike...
334
Long-term Depression
30.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
30.6K
Seizures: Classification
300
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
300


