疫苗接种对越南COVID-19结果的影响
Ngoc-Lan Thi Nguyen1,2, Hien Thi Thu Nguyen3,4, Vang Le-Quy5,6
1Hanoi Medical University Hospital, Hanoi 100000, Vietnam.
Diagnostics (Basel, Switzerland)
|January 8, 2025
概括
接种COVID-19疫苗显著降低了患者的死亡率和疾病严重程度. 增强和完全接种疫苗的个体经历了更好的结果,特别是老年人和患有慢性疾病的人.
科学领域:
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- COVID-19仍然是一个重大的全球健康问题.
- 疫苗接种是缓解严重疾病后果的主要策略.
- 了解疫苗在不同患者群体中的有效性至关重要.
研究的目的:
- 评估COVID-19疫苗接种状态对住院患者临床结果的影响.
- 评估接种疫苗 (未接种疫苗,部分接种疫苗,完全接种疫苗,再接种疫苗) 与疾病严重程度,死亡率和住院时间之间的关系.
- 为了确定COVID-19患者中严重疾病的关键预测因素.
主要方法:
- 在越南对3102名确诊的COVID-19患者进行了观察性研究.
- 将参与者分为未接种疫苗,部分接种疫苗 (PV),完全接种疫苗 (FV) 和增强疫苗的组.
- 回归分析以将疫苗状态与死亡率,持续症状和住院时间相关联.
主要成果:
- 严重的疾病在未接种疫苗的患者中更为普遍.
- 与FV和增强组相比,未接种疫苗和PV组中器官损伤的生物标志物增加.
- 接种疫苗状态,年龄和并发症 (高血压,糖尿病,心脏病,慢性病) 预测了严重疾病;未接种疫苗的死亡率最高 (5.2%对1.4%FV,增长0.3%).
结论:
- 据证明,COVID-19疫苗接种可以降低死亡率和疾病严重程度.
- 疫苗接种提供了显著的保护,特别是对于老年人和患有慢性并发病的人来说.
- 疫苗的有效性在不同的疫苗接种状态中是显而易见的,增强的个体显示出最好的结果.
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