内分泌干扰农药使用对肥胖的影响:系统性审查
Marcelino Pérez-Bermejo1, Cristian Barrezueta-Aguilar2, Javier Pérez-Murillo1
1SONEV Research Group, School of Medicine and Health Sciences, Catholic University of Valencia San Vicente Mártir, C/Quevedo nº 2, 46001 Valencia, Spain.
Biomedicines
|January 8, 2025
概括
某些农药,如pyrifos和 pyrethroids,可能通过破坏内分泌功能和改变新陈代谢,导致肥胖. 需要进一步的研究来证实农药暴露与体重增加之间的联系.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
背景情况:
- 内分泌干扰剂是干扰内分泌系统的化学物质.
- 杀虫剂是内分泌干扰剂的一类,与发育和甲状腺功能的改变有关,可能增加肥胖风险.
研究的目的:
- 系统地审查关于植物性食品中的农业农药与超重/肥胖之间的关联的临床和临床前证据.
主要方法:
- 按照PRISMA-2020指南进行系统审查.
- 分析调查内分泌干扰农药及其对肥胖的影响的研究.
主要成果:
- 有证据表明,pyrifos,pyrethroids和neonicotinoids可能通过改变新陈代谢和荷尔蒙水平 (例如,勒) 来促进肥胖.
- 周产期暴露于pyrifos或温克洛林可能会导致成年人体重增加.
- 一些农药 (boscalib,captan, thiacloprid,ziram) 与体重变化没有任何关联.
- 温克洛林暴露可能会增加跨代超重/肥胖的流行率.
结论:
- 现有研究将农药与肥胖症联系起来有局限性,包括方法问题和混变量.
- 需要更多高质量的研究来确定农药暴露与肥胖之间的确切因果关系.
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