非小细胞肺癌的免疫疗法:修改后的Delphi调查对一线治疗,特殊人群和再挑战的共识
Francesca Colonese1, Alessandra Bulotta2, Carlo Genova3,4
1Medical Oncology Unit, Fondazione IRCCS San Gerardo dei Tintori di Monza, 20900 Monza, Italy.
Biomedicines
|January 8, 2025
概括
意大利瘤学家就分子特征和免疫疗法对非小细胞肺癌 (NSCLC) 的重新挑战达成共识. 然而,在NSCLC管理中,关于最佳的第一线治疗方法和特殊人群的显著不确定性仍然存在.
科学领域:
- 在瘤学瘤学.
- 医学研究 医学研究
背景情况:
- 非小细胞肺癌 (NSCLC) 的治疗已经被免疫疗法彻底改变.
- 关于最优的第一线治疗方法,特殊群体的管理,以及NSCLC中免疫疗法重新挑战策略的不确定性仍然存在.
研究的目的:
- 调查意大利瘤学家对一线治疗方法,特殊群体和NSCLC免疫疗法再试的意见.
- 在意大利专家中确定NSCLC治疗策略的共识和不确定性的领域.
主要方法:
- 德尔菲调查对61名意大利瘤学家进行了调查.
- 两轮投票使用5点的利克尔特比例进行,以评估对起草的声明的同意.
- 共识被定义为至少75%的小组同意或不同意.
主要成果:
- 在第一轮中,只有23.2%的陈述达成一致,7.2%达成分歧,69.6%缺乏共识.
- 第二轮调查显示,13.5%的陈述达成一致,2.7%达成不同意,而83.8%的陈述仍然缺乏共识.
- 他们就分子特征的必要性,突变状态,吸烟史,类固醇治疗和免疫治疗重新挑战的必要性达成协议.
结论:
- 该研究突出了意大利瘤学家关于在NSCLC中使用免疫治疗的共识和重大不确定性的领域.
- 缺乏共识的领域为未来的临床研究提供了方向,以解决NSCLC的治疗模两可.
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