Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

192
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
192
Antidepressant Drugs: Overview01:25

Antidepressant Drugs: Overview

356
Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
356
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs01:28

Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs

299
Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
299
Depression: Overview01:18

Depression: Overview

213
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
213
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

42
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
42
Long-term Depression01:03

Long-term Depression

2.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Autoimmune Neuromuscular Disorders at a Molecular Crossroad: Linking Pathogenesis to Targeted Immunotherapy.

International journal of molecular sciences·2025
Same author

Fluid Biomarkers in Demyelinating Spectrum Disorders: Past, Present, and Prospects.

International journal of molecular sciences·2025
Same author

Cardiovascular Dysautonomia in Patients with Parkinson's Disease and Hypertension: A Cross-Sectional Pilot Study.

Journal of clinical medicine·2025
Same author

Understanding the Complex Dynamics of Immunosenescence in Multiple Sclerosis: From Pathogenesis to Treatment.

Biomedicines·2024
Same author

Neuroplasticity in Parkinson's disease.

Journal of neural transmission (Vienna, Austria : 1996)·2024
Same author

Health-Related Quality of Life in Romanian Patients with Dystonia: An Exploratory Study.

Journal of clinical medicine·2024

相关实验视频

Updated: Jun 3, 2025

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

600

探索抗抑郁药,抑郁症和神经认知障碍之间的复杂关系.

Monica Neațu1,2, Iulia Ioniță1,2, Ana Jugurt1,2

  • 1Department of Clinical Neurosciences, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Biomedicines
|January 8, 2025
PubMed
概括

在老年人中同时出现的痴呆和抑郁症需要综合治疗. 抗抑郁药可以提供神经保护,但具有风险,需要个性化护理策略以获得最佳结果.

关键词:
抗抑郁药是一种抗抑郁药.认知能力下降 认知能力下降痴呆症 痴呆症是一种痴呆症.抑郁 抑郁症 抑郁症 抑郁症 是一种

更多相关视频

Animal Models of Depression - Chronic Despair Model CDM
05:47

Animal Models of Depression - Chronic Despair Model CDM

Published on: September 23, 2021

7.1K
A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

20.8K

相关实验视频

Last Updated: Jun 3, 2025

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

600
Animal Models of Depression - Chronic Despair Model CDM
05:47

Animal Models of Depression - Chronic Despair Model CDM

Published on: September 23, 2021

7.1K
A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

20.8K

科学领域:

  • 老年病的医生 老年病的医生
  • 神经科学是一个神经科学.
  • 精神病学是一个精神病学.

背景情况:

  • 痴呆症和抑郁症经常在老年人中并存,从而创造了一个复杂的临床挑战.
  • 抑郁症是痴呆症的一个已知的危险因素,每一种情况都会使另一个情况恶化.
  • 同时管理对于预防疾病进展和认知衰退至关重要.

研究的目的:

  • 探索老年人群中抑郁症和痴呆症之间的复杂关系.
  • 检查与抗抑郁药物使用相关的潜在神经保护益处和风险.
  • 强调需要个性化治疗策略,平衡心理健康和认知保护.

主要方法:

  • 文献综述和现有关于抑郁症,痴呆症和抗抑郁药物的有效性研究的综合.
  • 对研究抗抑郁药对神经发生,突触可塑性和神经炎症的影响的分析.
  • 对抗抑郁药对阿尔茨海默氏症相关病理,包括粉样β和的作用的研究进行了审查.

主要成果:

  • 抗抑郁药可以提供神经保护作用,通过促进神经发生和减少炎症来减缓认知衰退.
  • 一些证据表明,抗抑郁药可以减轻阿尔茨海默氏症的病态,如粉样β积累和高酸化.
  • 治疗耐药性抑郁症在认知障碍的老年人中很常见,一些研究表明抗抑郁药可能会增加未被诊断的痴呆症的风险.

结论:

  • 综合治疗方法对于管理老年人的并发性抑郁症和痴呆症至关重要.
  • 抗抑郁药物治疗具有神经保护和风险的双重潜力,需要仔细考虑.
  • 个性化,全面的策略对于优化这些疾病的老年人心理健康和认知结果至关重要.