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乳酸是严重创伤性脑损伤患者不良结果的强有力的预测剂
Bharti Sharma1,2, Winston Jiang1,2, Yashoda Dhole2
1Department of Surgery, NYC Health and Hospitals, Elmhurst Hospital Center, New York, NY 11373, USA.
Biomedicines
|January 8, 2025
概括
严重创伤性脑损伤 (TBI) 患者的高乳酸水平 (LLs) 与更糟糕的结果相关,包括更长的住院时间和增加的死亡率. 监测LL可以预测TBI患者的不良临床结果.
科学领域:
- 神经科学是一个神经科学.
- 关键护理医学 关键护理医学
- 生物化学 生物化学
背景情况:
- 乳酸盐是糖解的代谢副产物,通常与细胞缺氧有关.
- 在危急病患者,特别是创伤性脑损伤 (TBI) 患者中,经常观察到乳酸水平升高.
研究的目的:
- 研究患有严重TBI的患者的乳酸盐水平 (LLs) 和临床结果之间的关联.
- 确定较高的LL是否预测该患者群体的临床结果较差.
主要方法:
- 一个回顾性,单中心研究,涉及严重TBI患者.
- 从2020年1月到2023年12月收集的数据,包括乳酸水平,伤害严重性得分 (ISS),格拉斯哥昏迷得分 (GCS),停留时间 (LOS),呼吸机日和死亡率.
主要成果:
- 乳酸盐水平与年龄的增加有显著的反向相关性.
- 较高的乳酸盐水平与增加的伤害严重性得分 (ISS) 有正相关,与格拉斯哥昏迷得分 (GCS) 有负相关.
- 在医院和ICU入院时乳酸水平升高与更长的住院和ICU停留时间,呼吸机日数增加和更高的死亡率显著相关. 在ICU入院期间的三角乳酸盐下降与更糟糕的结果相关.
结论:
- 乳酸盐水平作为严重TBI患者不良临床结果的强有力的预测生物标志物.
- 监测乳酸动态对于评估预后和指导严重TBI的管理至关重要.
- 这些发现强调了乳酸作为代谢困扰指标的重要性,以及它对TBI后患者康复的影响.
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