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肠道微生物群,细菌转移和中风:当前知识和未来方向
Cristina Granados-Martinez1,2, Nuria Alfageme-Lopez1, Manuel Navarro-Oviedo1,2
1Department of Pharmacology and Toxicology, School of Medicine, University Complutense of Madrid, 28040 Madrid, Spain.
Biomedicines
|January 8, 2025
概括
卒中幸存者通常会因为肠道微生物群的变化而患上感染. 来自肠道的细菌转移有助于这些感染,恶化结果. 针对微生物群-肠-大脑轴可能提供新的治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 在全球范围内,中风是导致死亡,残疾和痴呆的主要原因,治疗选择有限.
- 脑卒中后的免疫抑制和神经功能障碍增加了脑卒中相关感染 (SAI) 的风险.
- 现有的中风治疗方法,如纤维解析和血栓切除术,无法解决感染风险.
研究的目的:
- 审查最近关于中风后微生物群-肠-大脑轴 (MGBA) 变化的证据.
- 探索细菌转移 (BT) 在SAI发展中的作用.
- 讨论针对MGBA和BT的潜在治疗策略,以减少中风后并发症.
主要方法:
- 综述实验研究和关于中风病理生理学的最新文献.
- 分析肠道微生物群,肠道透性和细菌转移之间的联系.
- 综合目前对SIS的理解及其与MGBA的联系.
主要成果:
- 脑卒中会导致肠道微生物群的组成发生重大变化,并增加肠道的透性.
- 从肠道转移的细菌是导致SAI的一个关键机制.
- 高危性脑炎与中风患者的预后较差和死亡率增加有关.
结论:
- 微生物群-肠-大脑轴在中风后的并发症中发挥着关键作用,特别是SAI.
- 针对肠道失调和细菌转移,为新的中风疗法提供了一个有希望的途径.
- 旨在恢复肠道屏障功能和微生物群平衡的干预措施可以改善中风患者的结果.
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