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生物标记与甲状腺癌预后之间的相关性
Rami Hajjar1,2,3, Ciprian Duta1,2, Ionut Flaviu Faur1,2
1IInd Surgery Clinic, Timisoara Emergency County Hospital, 300723 Timisoara, Romania.
Biomedicines
|January 8, 2025
概括
在BRAF V600E突变表明更具侵略性的甲状腺癌. 甲状腺蛋白和素水平是预测甲状腺癌预后和指导个性化治疗的可靠标志物.
科学领域:
- 在瘤学瘤学.
- 生物标志物研究 生物标志物研究
- 癌症预后 癌症预后
背景情况:
- 全球甲状腺癌发病率上升,乳头甲状腺癌是最常见的亚型.
- 甲状腺癌亚型的预后不同,包括毛囊癌,髓癌和形癌.
- 需要更好地了解甲状腺癌的预后因素.
研究的目的:
- 调查甲状腺癌中BRAF V600E突变,甲状腺蛋白 (Tg) 和素的预后价值.
- 为了将这些生物标志物与瘤阶段,进展和患者存活率相关联.
- 评估这些标记在个性化治疗风险分层中的有用性.
主要方法:
- 在2010年至2018年期间接受治疗的395名甲状腺癌患者的回顾性分析.
- 根据BRAF V600E突变状态对患者进行分组.
- 用卡普兰-梅尔和考克斯回归方法测量手术前的铁血球蛋白和素水平,并使用生存分析.
主要成果:
- BRAF V600E突变与老年患者,晚期患者和更高的Tg/素水平相关.
- 升高的Tg和素水平与瘤进展和死亡风险增加相关.
- 较低的生物标志物水平 (<30 ng/mL Tg,<15 pg/mL calcitonin) 与明显更好的五年生存率 (82.1%与67.5%) 有关.
结论:
- BRAF V600E突变意味着甲状腺癌更具攻击性,结果更差.
- 甲状腺蛋白和素作为甲状腺癌的可靠预后指标.
- 这些标志物对于风险分层和开发个性化治疗策略至关重要,以提高患者的治疗结果.
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