在精神分裂症患者中,甘油三,残留胆固醇和全身炎症之间的不一致
Jeffrey Wang1, Maaike Kockx1, Gabrielle J Pennings1
1Atherosclerosis and Vascular Biology Laboratory, The ANZAC Research Institute, Concord Repatriation General Hospital, University of Sydney, Concord 2138, Australia.
在精神分裂症患者中,高甘油三和残留胆固醇是常见的,但与系统性炎症没有相关性,表明独立的心血管风险. 这一发现对于在这个人群中管理心脏病至关重要.
科学领域:
- 心血管疾病研究研究
- 精神疾病 精神疾病
- 代谢综合征是代谢综合征的一种.
背景情况:
- 过高甘油三血和全身炎症在精神分裂症患者中很普遍.
- 这些情况增加了心血管疾病 (CVD) 的风险.
- 过高的甘油三 (TGs),残留胆固醇和精神分裂症炎症之间的关联尚未得到充分理解.
研究的目的:
- 研究精神分裂症患者的脂质样本 (TG,残留胆固醇) 和全身炎症标志物之间的关系.
- 为了比较精神分裂症患者和健康对照人群之间的这些标志物.
- 确定脂质异常和炎症是否是精神分裂症中心血管疾病风险的独立贡献者.
主要方法:
- 评估了禁食脂质特征 (TG,TC,LDL-C,HDL-C,残留胆固醇) 和全身炎症标志物 (hsCRP,白细胞计数,差异,GlycA,细胞因子).
- 使用NMR进行Apolipoprotein B和GlycA评估;多重测定细胞因子水平.
- 对抗精神病药物治疗的147名精神分裂症患者与56名健康对照进行了比较.
主要成果:
- 与对照组相比,精神分裂症患者表现出高的TG,残留胆固醇,hsCRP,GlycA,白细胞计数和中性粒细胞与淋巴细胞比率 (NLR).
- 重要的是,TG和残留胆固醇与精神分裂症患者的全身炎症标志物没有相关性.
- 在患者中增加的互白素 (IL) - 10水平表明了抗炎特征,尽管有其他炎症标志物.
结论:
- 由于TG/残留胆固醇与精神分裂症的全身炎症之间缺乏关联,这表明它们是心血管疾病的独立风险因素.
- 这种不一致凸显了精神分裂症中心血管疾病复杂的病理生理学.
- 对精神分裂症中心血管疾病风险的管理策略可能需要单独解决脂质和炎症.
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