相关实验视频

Updated: Jun 3, 2025

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

在COVID-19和肺纤维化中重叠的系统蛋白与组织重塑和炎症相关

Barbora Svobodová¹, Anna Löfdahl¹, Annika Nybom¹

¹Lung Biology Unit, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden.

|January 8, 2025

概括

研究人员确定了关键蛋白质,如色素 (DCN) 和肝细胞生长因子 (HGF),可以预测COVID-19后的肺纤维化. 这些纤维化标志物与异常性肺纤维化 (IPF) 重叠,可以帮助识别有风险的患者.

科学领域:

肺部病理学肺部病理学
免疫学免疫学免疫学
生物化学生物化学

背景情况:

越来越多的患者在COVID-19感染后出现慢性肺纤维化.
识别患有COVID-19后肺纤维化风险的个体对于及时干预至关重要.

研究的目的:

在COVID-19患者中识别与异常性肺纤维化 (IPF) 中发现的纤维化标志物相关的系统性蛋白质.
为了确定这些重叠的蛋白质是否可以预测COVID-19引起的肺纤维化.

主要方法:

来自住院COVID-19患者 (中度和重度) 和健康个体的血样本使用近距离延伸试验 (PEA) 技术分析了92种蛋白质.
蛋白质面板包括炎症和组织重塑的标志物.
进行了解剖肺组织的组织病理学分析.

主要成果:

与健康对照人群相比,COVID-19患者的蛋白质如decorin (DCN),TNFRSF12A和CXCL13的水平升高,显示与IPF病理的重叠.
单细胞化疗蛋白-3 (MCP-3) 和肝细胞生长因子 (HGF) 的表达从中度到严重的COVID-19增加.
确定了几种细胞外基质和与炎症相关的蛋白质.

结论:

与细胞外矩阵重塑和炎症相关的蛋白质与COVID-19后肺纤维化有关.
迪科林 (DCN),TNFRSF12A,CXCL13,CXCL9,MCP-3和HGF是预测COVID-19严重程度和潜在的肺纤维化发展的有希望的生物标志物.

关键词:

在 COVID-19 疫情中,在DCN中使用DCN.在HGF的基础上.在IPF中,IPF是IPF.在MCP-3中,MCP-3是MCP-3.这就是TNFRSF12A.生物标志物生物标志物有纤维化的纤维化.

更多相关视频

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

Published on: March 21, 2021

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

相关概念视频

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

Pathophysiology of Heart Failure

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...