在婴儿血瘤患者的婴儿期内,普罗普拉诺洛尔治疗对神经发育的影响
Cenk Baykan1, Melike Mete Çiftseven2, Gonca Keskindemirci2,3
1Department of Child Health and Diseases, Istanbul Medical Faculty, İstanbul University, 34104 Istanbul, Turkey.
Children (Basel, Switzerland)
|January 8, 2025
概括
这项研究发现,在患有血瘤的婴儿中,普拉诺洛尔没有显著的神经发育副作用. 观察到的运动功能的差异并非归因于兰醇治疗本身.
科学领域:
- 儿科医学 儿科医学
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 婴儿血管瘤 (IH) 是婴儿常见的血管瘤.
- 普罗巴诺洛尔是IH的第一线治疗方法,但其长期的神经发育效应需要进一步研究.
- 了解潜在的副作用对于优化IH管理至关重要.
研究的目的:
- 评估婴儿的神经发育的结果,治疗IH的propranolol治疗的婴儿.
- 为了比较用propanolol治疗的IH患者,未治疗的IH患者和健康对照者之间的神经发育水平.
主要方法:
- 一个单一中心的横截面研究包括102名儿童:40名为IH接受了普罗兰诺洛尔治疗,31名未接受治疗的IH患者和31名健康对照.
- 使用贝利-III测试进行了神经发育评估.
- 收集了人口,临床,围产和产后数据.
主要成果:
- 两组之间没有观察到认知,语言或社会情感技能的显著差异.
- 在健康的对照组和兰醇治疗和未治疗的IH组之间发现了运动功能的显著差异 (p=0.006).
- 母亲的教育水平与认知,语言和运动功能有关; 父亲的教育与认知功能有关.
结论:
- 在这项研究中,用于婴儿血瘤的普罗普兰诺洛尔治疗没有显示出对神经发育的显著不良影响.
- 观察到的运动功能差异不仅仅归因于普拉拉诺洛尔,这表明可能涉及其他因素.
- 在神经发育结果方面,罗仍然是婴儿血管瘤的相对安全的治疗选择.
相关概念视频
01:27Adrenergic Antagonists: Pharmacological Actions of β-Receptor Blockers
528
β-receptor blockers significantly impact the cardiovascular system by counteracting catecholamine-induced sympathetic responses. These medications decrease heart rate, contractility, and cardiac output, potentially leading to cardiac depression, life-threatening bradycardia, and death. Therapeutically, β-blockers function as mild antihypertensives and are utilized in treating angina pectoris and cardiac arrhythmias. However, nonselective β-blockers inhibit β2-receptors in...
528
01:31Adrenergic Antagonists: ɑ and β-Receptor Blockers
405
Third-generation β-blockers, such as labetalol and carvedilol, represent a significant advancement in managing cardiovascular conditions. Unlike conventional β-blockers, which can induce peripheral vasoconstriction, third-generation drugs block α1 adrenoceptors. This promotes vasodilation through several mechanisms, such as increased nitric oxide production, inhibition of calcium ion entry, opening of potassium ion channels, and antioxidant action. Labetalol, for instance, is...
405
01:28Antihypertensive Drugs: Types of β-Blockers
578
β receptors are classified into three subclasses: β1, β2, and β3. β1 receptors are primarily located in the heart and kidneys. When they get activated, they increase heart rate, contractility, and renin release. This process enhances blood pressure and aids in stress management. In contrast, β2 receptors are situated mainly in the lungs, blood vessels, and skeletal muscles. Upon activation, they trigger smooth muscle relaxation, causing bronchodilation and...
578