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唐氏综合征中的星细胞变化和功能障碍:专注于神经发生,协同发生和神经回路形成

Beatrice Uguagliati1, Mariagrazia Grilli1

  • 1Laboratory of Neuroplasticity, Department of Pharmaceutical Sciences, University of Piemonte Orientale, 28100 Novara, Italy.

Cells
|January 8, 2025
PubMed
概括

唐氏综合征 (DS) 涉及过多星球细胞改变大脑发育,影响神经元生长和认知功能. 了解这些天体细胞变化可能会揭示DS患者智力障碍的新治疗点.

关键词:
星球细胞是星球细胞.天体质的诞生 (astrogliogenesis) 是一个唐氏综合征是什么意思神经发育的神经发育神经发生神经发生.有关突触的突触.

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Neurogenesis and Regeneration of Nervous Tissue01:15

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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