炎症性肠病和病:探索肠轴
Roberto de Sire1,2, Alessia La Mantia1, Livio Bonacci1
1IBD Unit, Department of Clinical Medicine and Surgery, University Federico II, 80126 Naples, Italy.
Life (Basel, Switzerland)
|January 8, 2025
概括
炎症性肠病 (IBD) 可能会导致脏问题,包括血球炎 (GN). 研究强调了肠-轴连接,强调需要了解IBD相关的病.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 炎症性肠病 (IBD) 超出了肠道,影响脏,增加死亡率.
- 在IBD中,脏表现,虽然未得到充分的认可,但包括结石,阻塞性尿路病,以及诸如球炎 (GN) 这样的体疾病.
- GN是一种与末期病 (ESKD) 相关的显著IBD肠外表现 (EIM).
研究的目的:
- 探索IBD相关脏病的基础.
- 专注于肠道炎症,失生症和 GN. glomerular 过程之间的病原性相互作用.
- 为了阐明与IBD相关的IgA脏病 (IgAN) 中的肠轴.
主要方法:
- 审查关于IBD和脏表现现现象的现有文献.
- 对与IBD相关联的研究分析.
- 研究肠-轴机制的研究.
主要成果:
- 很大一部分IBD患者经历脏干扰,往往被忽视.
- 淋巴细胞炎 (GN) 是一种关键的IBD相关病,可能导致ESKD.
- 新出现的证据支持肠道炎症/失生症和GN之间的病原性联系.
结论:
- 脏表现是IBD的关键EIM,需要更多的临床关注.
- 肠-轴在IBD相关的GN,特别是IgAN的发病过程中起着至关重要的作用.
- 对这一轴的进一步研究对于改善IBD相关病的诊断和治疗至关重要.
相关概念视频
Nephrons
2.1K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.1K
Inflammatory Bowel Disease II: Crohn's Disease
183
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
183
Inflammatory Bowel Disease I: Ulcerative Colitis
135
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
135
Renal Corpuscle
1.6K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
1.6K
Hormonal Regulation
32.9K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
32.9K
Chronic Bowel Disorders: Introduction
386
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
386


