治疗儿童的口腔微生物组动力学:一项比较研究
Zahirrah Begam Mohamed Rasheed1, Chew Wei Sheng2, Erika Norfitriah1
1Department of Craniofacial Diagnostics & Biosciences, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia.
Life (Basel, Switzerland)
|January 8, 2025
概括
儿童牙损伤治疗增加了口腔微生物群的多样性. 一些有益的细菌在治疗后减少,而潜在的有害细菌在治疗后增加,这凸显了持续口腔健康策略的需要.
科学领域:
- 微生物学 微生物学
- 儿科牙科 儿科牙科
- 口腔健康 口腔健康
背景情况:
- 牙是一种复杂的疾病,受宿主易感性,微生物活动和饮食碳水化合物的影响.
- 了解口腔微生物组的动态对于治疗儿科牙损伤至关重要.
研究的目的:
- 为了研究儿童在牙损伤治疗前后口腔微生物组的变化.
- 为了将口腔微生物组的变化与临床结果和人口因素相关联.
主要方法:
- 使用DMFT/dmft指数,从患有不同严重程度的虫 (无虫,中度,严重) 的儿童收集的唾液样本.
- 16S rRNA基因测序分析了牙科干预前和后的微生物组成 (3个月的随访).
主要成果:
- 在牙科治疗后,口腔微生物组的α多样性显著增加.
- 在治疗后,Actinobacteria和Firmicutes的数量减少,而Fusobacteria,Proteobacteria,Spirochaetota和Synergistota的数量增加 (p <0.05).
- 趋势显示,在属级别上Streptococcus的减少和Fusobacterium,Neisseria,Haemophilus和Leptotrichia的增加. 在属级别上,Streptococcus的减少和Fusobacterium,Neisseria,Haemophilus和Leptotrichia的增加.
结论:
- 马来西亚的儿童牙与年龄,社会经济地位和饮食有关.
- 牙科治疗增强了口腔微生物群的多样性,但并不能消除所有的菌细菌.
- 针对性口腔健康教育和对益生菌的研究是预防空的建议.
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