新生儿低血糖和神经发育结果 - - 更新的系统性审查和元分析
Shivashankar Diggikar1, Paula Trif2,3, Diana Mudura2
1Department of Pediatrics, Oyster Women and Child Hospital, Bengaluru 560043, India.
Life (Basel, Switzerland)
|January 8, 2025
概括
新生儿低血糖症与长期的神经发育问题有关,包括认知和视觉运动障碍. 新生儿的低血糖水平增加了这些不良结果的风险.
科学领域:
- 新生儿科学 新生儿科学
- 神经科学是一个神经科学.
- 发育儿科 发育儿科
背景情况:
- 新生儿低血糖症对大脑发育和神经结果构成风险.
- 现有证据强调需要对其长期影响进行更新分析.
研究的目的:
- 对新生儿低血糖症及其与神经发育结果的关联进行更新的元分析.
- 研究低血糖严重程度对长期神经功能的影响.
主要方法:
- 在主要数据库 (PubMed,CINAHL,Embase,CENTRAL) 进行系统的文献搜索,直到2024年3月.
- 包括随机/准随机试验和观察性研究.
- 随机效应模型元分析将神经发育障碍 (NDI),认知障碍和视觉运动障碍等结果结合起来.
主要成果:
- 在新生儿低血糖症和早期和中期儿童中NDI的更高率之间发现了显著的关联.
- 在低血糖婴儿中,认知障碍,视觉运动障碍和执行功能障碍的发病率增加.
- 证据质量通常低至非常低;NDI更常见的是血糖水平在20-34 mg/dL之间.
结论:
- 低质量的证据表明,新生儿早期低血糖症与长期神经发育问题之间存在联系.
- 进一步的高质量研究和延长后续对确认发现和确定精确的葡萄糖值至关重要.
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