相关实验视频

Updated: Jun 3, 2025

In vitro Mesothelial Clearance Assay that Models the Early Steps of Ovarian Cancer Metastasis

In vitro Mesothelial Clearance Assay that Models the Early Steps of Ovarian Cancer Metastasis

Published on: February 17, 2012

卵巢癌中的内皮功能障碍标志物:VTE风险和瘤预后结果

Inês Guerra de Melo^1,2, Valéria Tavares^1,2,3, Joana Savva-Bordalo⁴

¹Molecular Oncology and Viral Pathology Group, Research Centre of IPO Porto (CI-IPOP), Pathology and Laboratory Medicine Department, Clinical Pathology SV/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Centre (Porto. CCC), 4200-072 Porto, Portugal.

Life (Basel, Switzerland)

|January 8, 2025

概括

内皮功能障碍标志物影响卵巢癌预后和静脉血栓塞栓症风险. NOS3和SELP基因变异影响患者的生存率和血栓形成,这表明治疗向的背景依赖作用.

科学领域:

在瘤学瘤学.
遗传学是一个遗传学.
血管生物学血管生物学

背景情况:

卵巢癌 (OC) 由于晚期诊断和化疗抵抗,死亡率很高.
静脉血栓塞栓症 (VTE) 是癌症死亡的一个重要因素,与内皮功能障碍 (ED) 有关.
勃起障碍的炎症状态可能会独立地促进瘤的进展,这表明勃起障碍,静脉瘤和癌症预后之间存在联系.

研究的目的:

研究ED相关基因和单核酸多形态 (SNP) 对OC相关的VTE的影响.
评估ED标志物与OC患者预后之间的关联,独立于血栓形成.
探索ED标志物在OC进展和血栓形成中的潜在上下文依赖的作用.

主要方法:

在卵巢癌患者中分析ED相关基因和SNP.
基因表达/SNP变体与VTE发病率之间的关联的统计评估.
遗传标记与OC患者的整体存活率和无进展存活率的相关性.

主要成果:

*NOS3*基因上调与VTE发病率降低相关 (p=0.013).
*SELP*基因上调与较短的整体存活率相关 (p=0.048).
在没有预诊断VTE的患者中, *SELP* rs6136 T等位基因携带者表现出较低的无进展生存率 (p=0.038).

结论:

勃起障碍标志物在卵巢癌中表现出上下文依赖的作用,影响了血栓形成风险和患者预后.
特定的基因变异 (*NOS3*, *SELP*) 显示出潜在的预后指标.
在更大的队列和功能性研究中进一步验证对于澄清这些发现和开发治疗策略至关重要.

关键词:

在P-selectin中进行选择.它们的内皮质 (endothelium).氧化氧化是什么?卵巢瘤卵巢瘤多形态主义的多态主义.预后预后预后静脉血栓的形成静脉血栓的形成 ·威勒布兰德因素是什么

更多相关视频

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1

Published on: December 5, 2020

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence

Published on: November 2, 2014

相关概念视频

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

Regulation of Angiogenesis and Blood Supply

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...