比较长期结局在淋巴细胞疾病患者呈现脏综合征与脏范围蛋白尿病相比
Gabriel Ștefan1,2, Simona Stancu1,2, Adrian Zugravu1,2
1Department of Nephrology, Faculty of Medicine, University of Medicine and Pharmacy "Carol Davila", 050474 Bucharest, Romania.
Life (Basel, Switzerland)
|January 8, 2025
概括
这项研究比较了患有瘤综合征 (NS) 和瘤范围蛋白尿 (NRP) 的患者的结局. 虽然整体死亡率相似,但NS患者的脏存活率较低,这凸显了需要量身定制的管理.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内部医学 内部医学
- 淋巴细胞疾病 淋巴细胞疾病
背景情况:
- 蛋白尿显著影响慢性病 (CKD) 的进展.
- 有限的直接比较存在于活检诊断的淋巴细胞疾病 (GD) 患者的结核综合征 (NS) 和结核范围蛋白尿 (NRP) 的结局.
研究的目的:
- 为了比较NS和NRP之间的长期结果,在活检证明的淋巴细胞疾病的患者中.
- 在这个队列中确定与功能衰竭和死亡率相关的因素.
主要方法:
- 从2010-2015年对240名脏活检证明的GD患者进行了回顾性研究.
- 对于末期病 (ESKD),死亡或研究结束的情况,直到2022年1月的随访.
- 随访时间中位数为8.8年.
主要成果:
- 与NRP患者相比,NS患者 (59%) 更频繁地出现高血压,更高的eGFR,增加的蛋白尿和脂质失调.
- 在NS患者中,ESKD发生在35%,NRP患者中发生在39% (p=0.4).
- 多变量分析将NS,较低的eGFR,较高的慢性和糖尿病病与ESKD联系起来;较低的eGFR,较高的并发病率得分,以及糖尿病病与死亡率.
结论:
- 在NS和NRP之间没有观察到任何原因死亡率的显著差异.
- 调整后的分析表明NS患者的脏存活率较差.
- 个性化管理策略对于改善NS的GD患者的预后至关重要.
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