在接受甲状腺切除的患者中,甲状腺结节恶性的危险因素
Anna Krzentowska1, Filip Gołkowski1, Elżbieta Broniatowska2
1Department of Endocrinology and Internal Medicine, Medical College, Andrzej Frycz Modrzewski Krakow University, 30-705 Kraków, Poland.
Journal of clinical medicine
|January 8, 2025
概括
通过细针吸收活检 (FNAB) 准确诊断甲状腺结节至关重要. 贝塞斯达类别V表明恶性瘤的风险很高,特别是在年轻的患者中,需要手术.
科学领域:
- 内分泌学 在内分泌学.
- 手术瘤学手术瘤学
- 诊断病理学的诊断病理学
背景情况:
- 准确诊断甲状腺结节对于适当的患者管理至关重要,平衡及时治疗的需要与避免不必要的手术.
- 精细针吸收活检 (FNAB) 是一种主要的诊断工具,但其在不同诊断类别的准确性和影响需要持续评估.
- 组织病理学发现是确认甲状腺病变诊断的黄金标准.
研究的目的:
- 为了评估FNAB的诊断准确性,利用组织病理学作为参考标准.
- 分析每个贝塞斯达诊断类别 (DC) 的恶性瘤 (ROM) 风险.
- 评估患者年龄,性别,BMI,肥胖和淋巴细胞甲状腺炎对恶性瘤风险的影响.
主要方法:
- 对535名接受甲状腺手术的患者进行了回顾性分析.
- 将FNAB结果 (贝塞斯达分类) 与术后遗传学发现进行比较.
- 统计分析以确定恶性瘤的风险和人口统计和临床因素的影响.
主要成果:
- 恶性瘤 (ROM) 的风险在贝塞斯达 DC 之间有显著的差异,其中 DC V (91.0%) 和 VI (93.2%) 呈现最高率.
- 贝塞斯达DC V (几率比率[OR] 62.34) 和年龄≤50岁 (OR = 2.31) 是恶性瘤的统计学显著预测因素.
- DCs III和IV与恶性瘤风险增加没有显著关联 (OR = 1.68和OR = 1.51). 根据性别,BMI或肥胖,没有发现任何显著差异.
结论:
- 贝塞斯达DC V赋予了恶性瘤的高概率,特别是在50岁以下的患者中,强烈表明手术干预.
- 对于贝塞斯达DCsIII和IV,较低的恶性瘤风险表明,保守的管理与积极监测可能是适当的.
- 在50岁以下的贝塞斯达III或IV类患者中,由于潜在的风险增加,应考虑进行手术治疗.
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