患有/没有慢性阻塞性肺部疾病的吸烟者心脏代谢并发症的发生率:长期队列研究
Beatriz Herrero-Cortina1,2, Aura Maldonado-Guaje1, Jorge Rodriguez-Sanz1,3
1Precision Medicine in Respiratory Diseases Group, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria (IIS) de Aragón, 50009 Zaragoza, Spain.
Journal of clinical medicine
|January 8, 2025
概括
慢性阻塞性肺病 (COPD) 的新诊断和肺功能快速下降预测吸烟者的心脏代谢多病症 (CMM). 这些发现突出了这一群体发展多种慢性疾病的关键风险因素.
科学领域:
- 肺部病理学 肺部病理学
- 心脏病学 心脏病学
- 代谢疾病 代谢疾病
背景情况:
- 心脏代谢多病症 (CMM) 是一个重大的全球健康挑战.
- 吸烟者中CMM发展的预测因素尚未得到充分了解.
- 慢性阻塞性肺病 (COPD) 在吸烟者中很普遍.
研究的目的:
- 为了确定新的COPD诊断是否预测吸烟者中发生的CMM.
- 调查肺功能下降的速度是否预测吸烟者中发生的CMM.
- CMM被定义为至少两种情况:大脑心血管疾病,高血压,失脂症或糖尿病.
主要方法:
- 对前期从没有先前COPD或心脏代谢疾病的吸烟者收集的数据进行了纵向观察分析.
- 基线数据包括社会人口统计,BMI,吸烟史,症状和住院病例.
- 在基线和随访时测量了肺功能 (FEV1);使用了Cox比例危险模型.
主要成果:
- 在391名吸烟者中,有207人被新诊断患有COPD.
- 在约10年后,34%的人患有CMM,与年龄较大,BMI较高,吸烟史和基线COPD相关.
- 一个COPD诊断和加速的肺功能下降 (ΔFEV1 ≥40mL/年) 独立预测CMM.
结论:
- 新的COPD诊断是吸烟者中CMM发展的重要预测因素.
- 加快的肺功能下降也独立地与吸烟者的CMM风险增加有关.
- 这些发现强调了吸烟者呼吸系统健康和心脏代谢结果之间的联系.
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