在炎症性肠病中怀孕:来自德国现实世界队列的数据
Mousa Ayoub1, Anna Muzalyova2, Alanna Ebigbo1
1Internal Medicine III, University Hospital Augsburg, 86156 Augsburg, Germany.
Journal of clinical medicine
|January 8, 2025
概括
在受孕前缓解的炎症性肠病 (IBD) 妇女没有增加怀孕并发症的风险. 然而,怀孕期间活跃的IBD疾病与更高的妊娠糖尿病和发烧率有关.
科学领域:
- 胃肠病学 胃肠病学
- 生殖医学 生殖医学
- 公共卫生 公共卫生
背景情况:
- 炎症性肠道疾病 (IBD) 经常影响个体在他们的生殖年龄,需要清楚地了解怀孕的风险.
- 在患者和医疗保健提供者之间,有关IBD和怀孕管理的知识有限且往往不准确.
- 有效的怀孕管理需要解决IBD活动,并为患者提供准确的信息,以便明智地做出决策.
研究的目的:
- 为了评估患有炎症性肠病 (IBD) 的患者的妊娠并发症,按疾病活动分层.
- 评估患有慢性炎症疾病的孕妇患者的护理标准.
- 分析父亲患有IBD的孩子的结果.
主要方法:
- 单中心,混合方法研究 (追溯和前性),包括有子女的IBD患者.
- 分析临床数据,疾病进展,怀孕过程和IBD妇女的并发症.
- 对IBD患者进行了为期六个月的关于怀孕相关主题的调查,以补充临床数据.
主要成果:
- 在包括的134名IBD患者中,85%的女性在怀孕前处于缓解期.
- 在怀孕前IBD缓解的妇女没有增加诸如子宫前或胎盘断裂等并发症的风险.
- 怀孕期间活跃的IBD与更高的妊娠糖尿病率 (25%vs10%) 和发烧相比缓解.
结论:
- 在怀孕之前的炎症性肠病 (IBD) 缓解与与一般人群相似的妊娠并发症风险有关.
- 怀孕时活跃的IBD增加了不良妊娠结果的可能性,包括妊娠糖尿病和发烧.
- 在怀孕期间加强对IBD药物安全性的患者教育对于减轻并发症至关重要.
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