儿科神经和神经精神疾病中的时代生物学:与生物钟协调护理
Gabriele Giannotta1, Marta Ruggiero1, Antonio Trabacca2
1Associazione "La Nostra Famiglia", IRCCS "E. Medea", Scientific Hospital for Neurorehabilitation, Unit for Severe Disabilities in Developmental Age and Young Adults, Developmental Neurology and Neurorehabilitation, 72100 Brindisi, Italy.
Journal of clinical medicine
|January 8, 2025
概括
循环节律障碍在儿科神经和神经精神疾病中很常见,影响睡眠和情绪. 时间疗法,包括黑激素和光疗,在改善ADHD和ASD等疾病的儿童的症状方面表现有前途.
科学领域:
- 儿科时间生物学 儿科时间生物学
- 神经学和神经精神疾病
- 循环节律的研究研究.
背景情况:
- 时间生物学越来越多地被认为对儿科神经和神经精神疾病的作用,如,自闭症谱系障碍 (ASD),注意力缺陷/多动症障碍 (ADHD) 和创伤后应激障碍 (PTSD).
- 昼夜节律的障碍与核心症状有关,包括睡眠障碍,情绪失调和受影响儿童的认知障碍.
- 这些发现表明,基于时代生物学的治疗策略可能提供新的治疗途径.
研究的目的:
- 系统地审查有关儿童神经和神经精神疾病时的时代生物学现有文献.
- 为了确定昼夜节律扰乱的模式,并评估慢性治疗干预措施的有效性.
- 突出时间生物学对临床实践和未来研究方向的影响.
主要方法:
- 一个叙事审查,利用PubMed,ScienceDirect和Scopus数据库的系统搜索,直到2024年7月.
- 纳入标准集中在英语文章中,详细介绍儿童群体中昼夜节律的临床特征,治疗方法或结果,但不包括非同行评审的研究.
- 关键词包括"时间生物学"",生物节奏"",儿科"","",ADHD"和"ASD". 文章选和重复删除使用Rayyan软件进行管理.
主要成果:
- 对87项研究的分析显示,在所研究的儿科疾病中,持续存在的昼夜节律障碍.
- 在患有自闭症,多动症和创伤后应激障碍的儿童中观察到黑色素和皮质醇分泌失调,与睡眠和情绪问题相关.
- 在儿科症中发现了核心时钟基因的变化,与发作频率有关. 时间治疗干预措施,如黑激素和光疗,对睡眠和症状产生了积极的影响.
结论:
- 循环节律障碍在儿科神经和神经精神疾病中起着重要作用,直接影响治疗策略.
- 时间疗法包括黑激素,光和行为干预,是改善症状和整体功能的一种有希望的方法.
- 将慢性疗法纳入临床实践可能会将治疗范式转变为针对性,基于节奏的干预措施,需要进一步研究分子机制和个性化方法.
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