在住院期间在重症监护室停留期间与医院获得的血液感染有关-基于人口的队列研究
Kim Oren Gradel1,2, John Eugenio Coia2, Ming Chen3,4
1Center for Clinical Epidemiology, Odense University Hospital, Kløvervænget 30, Entrance 216, Ground Floor, DK-5000 Odense C, Denmark.
医院获得的血液感染 (HA-BSI) 显示出多种不同的病原体和结果. 在重症监护室 (ICU) 住院后获得HA-BSI的患者的死亡率较低,尽管存在类似的风险因素.
科学领域:
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
- 流行病学 流行病学
背景情况:
- 医院获得的血液感染 (HA-BSI) 是医疗保健机构的一个重大问题.
- 对于与重症监护室 (ICU) 住院有关的HA-BSI的特定临床特征和致病原体的了解有限.
研究的目的:
- 调查HA-BSIs的临床特征和微生物特征.
- 根据他们的ICU住院状态,对HA-BSI患者的结果进行比较,包括死亡率.
主要方法:
- 使用2009-2016年丹麦国家数据进行了基于人口的队列研究.
- 首次出现HA-BSI的患者被分为四组:非ICU,ICU前,ICU内和ICU后.
- 分析了微生物学数据,临床特征和死亡率 (28天和>28天).
主要成果:
- 在6888名HA-BSI患者中,在小组之间观察到微生物患病率的显著差异 (例如,在ICU患者中,Enterococci更高).
- 28天死亡率有显著差异:26.3% (非ICU),45.0% (ICU前),35.6% (ICU内) 和19.0% (ICU后).
- 在ICU后的患者表现出最低的28天死亡率,尽管年龄和并发病概况相似.
结论:
- 在由ICU住院定义的HA-BSI组之间存在微生物模式和患者预后的明显差异.
- 与ICU护理相比,HA-BSI获得的时间是影响患者结果的关键因素.
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