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在耳植入物上的生物膜的开发和预防:系统性审查
Alexios Tsikopoulos1, Konstantinos Tsikopoulos1, Konstantinos Sidiropoulos2,3
11st Department of Pharmacology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Medicina (Kaunas, Lithuania)
|January 8, 2025
概括
耳植入物 (CI) 上的生物膜形成是一个重要的外科手术挑战. 这篇评论强调了常见的生物膜位置,关键的细菌罪祸首,如S. aureus和P. aeruginosa,以及有希望的实验性预防策略.
科学领域:
- 医学微生物学 医学微生物学
- 生物材料科学 生物材料科学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 耳植入物 (CI) 上的生物膜形成是一个关键问题,往往需要装置探索和修复手术.
- 开发有效和经济的生物膜检测和预防方法对于改善CI结果至关重要.
研究的目的:
- 系统地审查关于耳植入物上的生物膜发育的文献.
- 研究和总结用于防止CI上的生物膜形成的实验策略.
主要方法:
- 在PubMed,Scopus和ScienceDirect进行了全面的系统文献搜索,截至2024年6月15日.
- 包括的研究 (n=26) 用修改的综合报告标准,乔安娜·布里格斯研究所的工具,Delphi技术和ROBINS-I.等方法进行了批判性评估.
- 对生物膜形成和抗生物膜剂疗效的数据进行了合成.
主要成果:
- 生物膜主要殖民于CI深处,如磁铁口袋,而不是光滑的表面.
- 黄金葡萄球菌和Pseudomonas aeruginosa是最常被发现的强大的生物膜产生微生物.
- 爆炸仍然是生物膜感染的CI的主要治疗方法,尽管许多实验性预防方法显示出显著的抗生物膜活性.
结论:
- 生物膜污染CIs代表严重并发症与有限的确定的治疗指南.
- 目前选择的治疗包括IC移除和/或替换.
- 实验性抗生素片策略表明,在体内和体外预防方面有相当大的前景.
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