与自我报告的祖先/族群相关的口腔微生物群的多样性和特征
Qingguo Wang1, Bing-Yan Wang2, She'Neka Williams3
1School of Medicine, Meharry Medical College, Nashville, TN 37208, USA.
International journal of molecular sciences
|January 8, 2025
概括
口腔微生物组的组成和功能在非洲裔美国人,高加索裔美国人和西班牙裔美国人群体之间有很大差异. 这些差异可能会影响牙周病风险和抗生素耐药性,为个性化治疗铺平道路.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 牙周病学 牙周病学
背景情况:
- 牙周炎的患病率和严重程度在不同的遗传祖先/种族群体中有所不同.
- 了解口腔微生物群的变异对于解决健康差异至关重要.
研究的目的:
- 与遗传祖先相关的口腔微生物组的特征.
- 确定祖先/族群之间的微生物多样性,丰富性和功能潜力的差异.
主要方法:
- 从自称非洲裔美国人 (AAs),白人美国人 (CA) 和西班牙裔美国人 (HA) 收集了161个牙斑样本.
- 利用Illumina NovaSeq测序用于微生物DNA的高通量分析.
- 分析了微生物种群的多样性,丰富性和功能基因配置文件.
主要成果:
- 在AA,CA和HA组中观察到口腔微生物种群多样性和丰度的显著差异.
- 在特定的祖先/族群中,发现了独特的微生物物种.
- 亚糖表现出更大的多样性和抗生素耐药基因和基因的多样性和丰富性,用于糖合物/多糖化物修饰.
结论:
- 口腔微生物组的变异与遗传祖先有关,影响毒性和抗生素耐药性.
- 这些发现支持开发精准医学,用于预防和治疗牙周病.
- 解决祖先/民族微生物群的差异可以帮助减少口腔健康差异.
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