牛乳酸增强了plasmacytoid树突细胞中的收费类受体7反应,并调节了细胞免疫力
Takumi Yago1, Asuka Tada2, Shutaro Kubo1
1R&D Division, Morinaga Milk Industry Co., Ltd., Zama 252-8583, Japan.
International journal of molecular sciences
|January 8, 2025
概括
牛乳酸 (LF) 通过托尔类受体7 (TLR7) 信号传递增强了血类树突细胞 (pDC) 对病毒RNA的反应. 乳清可促进干扰素α的产生,并激活免疫细胞,这表明它在抗病毒免疫力中起作用.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 生物化学 生物化学
背景情况:
- 等离子体树突细胞 (pDCs) 是先天免疫的关键参与者,利用Toll-like受体7 (TLR7) 检测病毒单链RNA (ssRNA) 并产生干扰素-α (IFN-α).
- 牛乳酸 (LF) 是一种具有已知的免疫调节特性的多功能蛋白质.
研究的目的:
- 研究牛乳酸 (LF) 对pDCs中TLR7介导的免疫反应的影响.
- 阐明LF吸收的机制及其对先天性和适应性免疫细胞激活的影响.
主要方法:
- 使用的TLR7记者THP-1细胞和人体外围血液单核细胞 (PBMCs) 活体外.
- 刺激细胞与R-848 (TLR7激动剂) 在存在或不存在的LF.
- 评估IFN-α的产生,基因表达 (IFN-α,HLA-DR,CD86,CD69,IFN-γ) 和通过细胞化或核介导的内细胞化通过LF的吸收.
主要成果:
- 在THP-1细胞中,LF增强了R-848诱导的IFN调节因子激活和IFN-α基因表达.
- 在PBMC超级生物中,LF增加了IFN-α水平,并在pDC中增加了IFN-α,HLA-DR和CD86的表达.
- 此外,LF还增强了髓状树突细胞中的HLA-DR和CD86,NK和T杀伤细胞中的CD69,T辅助型1和B细胞中的IFN-γ. 细胞吸收取决于细胞分裂或核相互作用.
结论:
- 牛乳酸增强了pDCs中的TLR7信号,促进IFN-α的产生,并激活各种先天性和适应性免疫细胞.
- 细胞吸收通过细胞体或核介导的内细胞体发生,这表明细胞体调节对ssRNA病毒的抗病毒免疫力,并有助于免疫恒常.
相关概念视频
Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
B Cell Activation and Differentiation
1.6K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.6K
T Cell Activation and Clonal Selection
651
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
651
T Cell Types and Functions
946
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
946
Cell-mediated Immune Responses
66.8K
Overview
66.8K
Special Features of Adaptive Immunity
744
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
744


