Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Protein and Protein Structure02:15

Protein and Protein Structure

78.3K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
78.3K
Protein Organization01:24

Protein Organization

6.2K
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....
6.2K
Protein and Protein Structures02:15

Protein and Protein Structures

10.3K
10.3K
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

10.8K
Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
10.8K
Protein Folding Quality Check in the RER01:29

Protein Folding Quality Check in the RER

3.7K
ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...
3.7K
Conservation of Protein Domains02:26

Conservation of Protein Domains

3.1K
3.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Learning what and how to describe: longitudinal development of content selection and strategy application in audio description training.

Frontiers in psychology·2026
Same author

Mechanism of action of Houttuynia cordata extract and its application in animal production.

Frontiers in veterinary science·2026
Same author

A versatile method for accurately predicting electronic absorption spectra of tetrapyrrole macrocycles.

Scientific reports·2026
Same author

Defining Activity-Based Subgroups in Multiple Sclerosis: A Review and Framework Proposal.

European journal of neurology·2026
Same author

A Multifunctional Near-Infrared Platinum(II) Agent for High-Performance Chemo-Photothermal Therapy.

Journal of the American Chemical Society·2026
Same author

Vertical Interaction between Thiourea and Perovskite Surface Results in Obviously Enhanced Performance with PCE Surpassing 24% Efficiency.

ACS applied materials & interfaces·2026

相关实验视频

Updated: Jun 3, 2025

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

68.5K

MHTAPred-SS:一个高度准的自编码器驱动的深度多任务学习框架,用于准确预测蛋白质二次结构.

Runqiu Feng1, Xun Wang1, Zhijun Xia1

  • 1Qingdao Institute of Software, College of Computer Science and Technology, China University of Petroleum (East China), Qingdao 266580, China.

International journal of molecular sciences
|January 8, 2025
PubMed
概括

MHTAPred-SS通过融合六个功能,包括语言模型嵌入,提高了蛋白质二级结构预测 (PSSP). 这种新的框架提高了准确性,特别是在单一类别和边界预测方面,有助于生物制药研究.

关键词:
深度的多任务学习.高度准的自动编码器.多功能的聚变聚变.预训练的蛋白质语言模型模型.蛋白质的二次结构预测和预测.

更多相关视频

The ITS2 Database
16:17

The ITS2 Database

Published on: March 12, 2012

30.7K
RNA Secondary Structure Prediction Using High-throughput SHAPE
13:42

RNA Secondary Structure Prediction Using High-throughput SHAPE

Published on: May 31, 2013

31.4K

相关实验视频

Last Updated: Jun 3, 2025

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

68.5K
The ITS2 Database
16:17

The ITS2 Database

Published on: March 12, 2012

30.7K
RNA Secondary Structure Prediction Using High-throughput SHAPE
13:42

RNA Secondary Structure Prediction Using High-throughput SHAPE

Published on: May 31, 2013

31.4K

科学领域:

  • 计算生物学 计算生物学
  • 结构生物信息学 结构生物信息学
  • 机器学习在生物学中的应用

背景情况:

  • 准确的蛋白质二次结构预测 (PSSP) 对生物制药和疾病诊断至关重要.
  • 当前的PSSP方法在同类蛋白质稀缺时,与功能空间利用和性能退化作斗争.
  • 现有堆叠网络架构的功能提取和学习策略存在局限性.

研究的目的:

  • 开发一个新的PSSP框架,MHTAPred-SS,克服当前方法的局限性.
  • 通过多特征融合方法来提高特征表示和预测准确性.
  • 为了使强大的PSSP独立于同类蛋白质的可用性.

主要方法:

  • 拟议的MHTAPred-SS框架整合了六个不同的特征,包括从预先训练的蛋白质语言模型中嵌入.
  • 引入了一个高度向的自编码器 (HTA) 用于同类蛋白质独立序列编码.
  • 开发了一种基于生物知识的多任务学习 (PSSP-MTL) 的蛋白质二次结构预测模型.

主要成果:

  • MHTAPred-SS在六个独立测试集 (包括TEST2016数据集) 上实现了最先进的性能.
  • 在TEST2016上实现了高Q3 (88.14%),SOV3 (84.89%),Q8 (78.74%) 和SOV8 (77.15%) 的指标.
  • 在预测单一类别和边界二次结构方面表现出显著的优势,精细捕捉了细分分布.

结论:

  • MHTAPred-SS在蛋白质二次结构预测准确性和稳定性方面取得了重大进展.
  • 该框架在有限的同源序列中表现良好的能力扩大了其适用性.
  • 改进的二次结构预测有助于加强结构生物学和药物发现的下游任务.