相关实验视频

Updated: Jun 3, 2025

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
06:10

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Published on: May 9, 2025

114

基因工程T细胞和重组抗体以准细胞内新抗原:当前状况和未来方向

Ana Maria Waaga-Gasser1, Thomas Böldicke2

  • 1Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

International journal of molecular sciences
|January 8, 2025
PubMed
概括

工程T细胞疗法,包括T细胞受体 (TCR) -T细胞和仿真抗原受体 (CAR) -T细胞,在向细胞内新抗原方面表现有前途. 将这些与基因组编辑和检查点抑制剂相结合,可能会提高临床应用的疗效.

关键词:
CD3 × TCR 类抗体) 的发生.基于CRISPR/Cas9的基因组编辑星星们的星星T 汽车的车辆.这就是TCR-CARs.类似于TCR的CARs就是TCR.与TCR类似的抗体.两种特异性抗体 (CD3 × TCR) 的情况.检查点阻断抗体的检查点在人体内新抗原是一种新抗原.治疗性的mRNA.

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